Results 31 to 40 of about 354,007 (274)

Expert opinion on montelukast and acebrophylline combination in the management of asthma

Indian Journal of Allergy Asthma and Immunology, 2021
Asthma control is highly inadequate in India, with worse outcomes and poor adherence to inhaled corticosteroids (ICSs). As per the Global Initiative for Asthma guidelines, leukotriene receptor antagonist (LTRA) can be added when a low-to-moderate dose of
N H Krishna, Amita Nene, Mahavir Modi, Tanvir Reza, Ashwin Songara, Vikrant Deshmukh   +5 more
doaj   +1 more source

Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice

Journal of Pharmacological Sciences, 2010
We investigated pharmacological characteristics of the itch-associated response to chronic dermatitis induced by 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) repeated application in mice.
Yukihito Tsukumo, Daisuke Harada, Haruhiko Manabe   +2 more
doaj   +1 more source

Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

Journal of Pharmacological Sciences, 2007
This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice.
Yasushi Kuraishi, Eiji Ohtsuka, Tasuku Nakano, Sanae Kawai, Tsugunobu Andoh, Hiroshi Nojima, Kiyoshi Kamimura   +6 more
doaj   +1 more source

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +1 more source

Leukotriene receptor antagonist therapy [PDF]

Postgraduate Medical Journal, 2000
Leukotriene receptor antagonists (LTRA) are a new class of drugs for asthma treatment, available in tablet form. Their unique mechanism of action results in a combination of both bronchodilator and anti-inflammatory effects. While their optimal place in asthma management is still under review, LTRA represent an important advance in asthma ...
openaire   +2 more sources

Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H1-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat

Journal of Pharmacological Sciences, 2013
.: An attempt was made to clarify the additive suppressive effects of pranlukast, a cysteinyl leukotriene–receptor (LTR) antagonist, in combination with chlorpheniramine, an antihistamine, on the up-regulation of histamine H1–receptor (H1R) mRNA in ...
Wakana Kuroda, Yoshiaki Kitamura, Hiroyuki Mizuguchi, Yuko Miyamoto, Bukasa Kalubi, Hiroyuki Fukui, Noriaki Takeda   +6 more
doaj   +1 more source

Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate

Results in Chemistry, 2023
γ-Hydroxyalkenals, 4-hydroxynonenal (HNE) and phospholipid esters of 4-hydroxy-8-oxooctenoic acid (HOOA-PL), are produced from the alkyl and carboxyl termini of arachidonyl phospholipids by radical-induced oxidative cleavage. Metabolism of HNE by Michael
Mikhail Linetsky, Anshula Mondal, Si-Yang Liu, Abby M. Hite, Shravani Enduri, Yu-Shiuan Cheng, Beatriz Feijo, Graham Kang, Nana Arhin, Hong Zeng, Olivia R. Laniak, John Denker, Robert G. Salomon   +12 more
doaj   +1 more source

Montelukast Has no Impact on the Systemic Production of TGFβ-1 in Patients with Nasal Polyposis Associated with Aspirin Intolerance

International Archives of Otorhinolaryngology, 2021
Introduction Nasal polyposis is a disease characterized by a mechanical dysfunction of the nasal mucosa, closely related to the unique makeup of its extracellular matrix, which develops as the result of an anomalous tissue remodeling process ...
Rogério Pezato, Luciano Lobato Gregório, Claudina Pérez-Novo, Thiago Ferreira Pinto Bezerra, Eduardo Macoto Kosugi   +4 more
doaj   +1 more source

Inflammatory modulation of the response of bronchial epithelial cells to lipopolysaccharide with pretreatment by montelukast [PDF]

Kragujevac Journal of Science, 2022
Montelukast, a leukotriene receptor antagonist, is the most prescribed nonsteroidal anti-inflammatory drug used as an add-on therapy for asthma. Besides its effect on blocking leukotriene action, montelukast has been proposed to have secondary anti ...
Jendrišek Gorana, Nikolić Aleksandra, Dragičević Sandra   +2 more
doaj   +1 more source

Effect of a leukotriene receptor antagonist on cough receptor sensitivity and allergen-induced cough in a patient with atopic cough variant asthma

Allergology International, 1998
A 24-year-old female patient with chronic dry cough, without wheezing and other symptoms, was diagnosed as atopic cough variant asthma (CVA) sensitized with house dust (HD) mite.
Hideko Kobayashi, Kenji Minoguchi, Yasuro Kohno, Naruhito Oda, Takuya Yokoe, Norio Kihara, Mitsuru Adachi   +6 more
doaj   +1 more source