Results 11 to 20 of about 68,425 (301)
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Leukotriene mechanisms of allergic enterocolitis pathogenesis in young children
Zaporožskij Medicinskij Žurnal, 2018 Purpose of the study was to determine the parameters of lipid mediators of allergic inflammation (cysteinyl leukotrienes C4, D4, E4) by enzyme immunoassay in serum, saliva, urine of young children with allergic enterocolitis.Materials and methods.
O. H. Shadrin, H. A. Haiduchyk
doaj +1 more source
Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]
, 2009 The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S +2 more
core +1 more source
Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. [PDF]
, 2016 Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung.
Austen, K Frank +5 more
core +1 more source
A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting Leukotrienes
Frontiers in Pharmacology, 2020 SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) has wreaked havoc during the global pandemic of 2020 infecting millions and leaving over a half million dead.
Colin D. Funk +2 more
doaj +1 more source
Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma. [PDF]
, 2019 BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology.
Gibson, Robert A +8 more
core +1 more source
LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism [PDF]
, 2016 A
Bachert, Claus +4 more
core +2 more sources
Mediators of Inflammation, 2017 Leukotrienes are inflammatory mediators that actively participate in the inflammatory response and host defense against pathogens. However, leukotrienes also participate in chronic inflammatory diseases. 5-lipoxygenase is a key enzyme in the biosynthesis
Luc H. Boudreau +6 more
doaj +1 more source
Role of Leukotrienes and Leukotriene Modifiers in Asthma
Pharmaceuticals, 2010 Leukotrienes (LTs), including cysteinyl LTs (CysLTs) and LTB4, are potent lipid mediators that are pivotal in the pathophysiology of asthma phenotypes. At least two receptor subtypes for CysLTs – CysLT1 and CysLT2 – have been identified.
Paolo Montuschi
doaj +1 more source