Results 91 to 100 of about 40,750 (280)

A guide to neuromodulation in drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Abstract Neuromodulation is approved for the treatment of drug‐resistant epilepsy. It has been increasingly utilized over the past two decades with the approval of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in addition to vagus nerve stimulation (VNS)—particularly in patients who are not deemed to be good resective surgical ...
Prachi Parikh, Irena Dolezawa, Manu Hegde, Lukas Imbach, Brian N. Lundstrom, Francesca Pizzo, Vikram R. Rao, Jaysingh Singh, Derek Southwell, Satsuke Watanabe, Birgit Frauscher   +10 more
wiley   +1 more source

An Adult with Episodic Abnormal Limb Posturing [PDF]

, 2018
info:eu-repo/semantics ...
Costa, C, Leitão, L, Lobo, P, Rebordão, L, Santos, M   +4 more
core   +1 more source

Effectiveness and safety of cenobamate after conversion to monotherapy or dual therapy in real‐world clinical practice

Epileptic Disorders, EarlyView.
Abstract Objective Patients with drug‐resistant epilepsy (DRE) typically take multiple anti‐seizure medications (ASMs) and are at risk of treatment‐related adverse events (AEs). This study assessed the impact of cenobamate monotherapy or dual therapy in patients with drug‐resistant epilepsy.
Álvaro Sánchez‐Guijo Benavente, Guillermina García Martín, Estuardo Daniel Castro Ruiz, Pablo Cabezudo García, Yolanda López Moreno, José Carlos Estévez María, Irene Lorite Fuentes, Sergio Navarro Conti, Raquel Calle Calle, Alejandro Fernández Cabrera, Isabel Ros González, Dulce Campos Blanco, María Isabel Chamorro Muñoz, Pedro Jesús Serrano Castro   +13 more
wiley   +1 more source

Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [PDF]

, 2019
The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities.
Alcántara, Andrés R., Domínguez de María, Pablo, Gonzalo Calvo, Gonzalo de   +2 more
core   +3 more sources

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures

Neuropsychiatric Disease and Treatment, 2009
Carol M Ulloa, Allen Towfigh, Joseph SafdiehDepartment of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USAAbstract: Levetiracetam is a second-generation antiepileptic drug (AED) with a unique chemical structure ...
Carol M Ulloa, Allen Towfigh, Joseph Safdieh   +2 more
doaj  

Levetiracetam Affects Differentially Presynaptic Proteins in Rat Cerebral Cortex

Frontiers in Cellular Neuroscience, 2017
Presynaptic proteins are potential therapeutic targets for epilepsy and other neurological diseases. We tested the hypothesis that chronic treatment with the SV2A ligand levetiracetam affects the expression of other presynaptic proteins.
Daniele Marcotulli, Giorgia Fattorini, Giorgia Fattorini, Luca Bragina, Luca Bragina, Jessica Perugini, Fiorenzo Conti, Fiorenzo Conti   +7 more
doaj   +1 more source

The second unprovoked seizure in a cohort of treated patients with a first unprovoked seizure

Epileptic Disorders, EarlyView.
Abstract Objectives To evaluate the rate of a second unprovoked seizure in antiseizure medications (ASMs)‐treated patients following a first unprovoked seizure and to identify potential risk factors associated with its occurrence. Methods A retrospective review of the computerized database and the medical records of all the patients who presented to ...
Revital Gandelman‐Marton, Jacques Theitler   +1 more
wiley   +1 more source

Symptomatic seizures in preterm newborns: a review on clinical features and prognosis [PDF]

, 2018
Neonatal seizures are the most common neurological event in newborns, showing higher prevalence in preterm than in full-term infants. In the majority of cases they represent acute symptomatic phenomena, the main etiologies being intraventricular ...
Corsello G, Deolmi M, Falsaperla R, Pisani F, Spagnoli C   +4 more
core   +2 more sources

Prognostic value of early magnetic resonance imaging in dogs after traumatic brain injury: 50 cases [PDF]

, 2014
Retrospective study of dogs with TBI that underwent 1.5T MRI within 14 days after head trauma. MRI evaluators were blinded to the clinical presentation, and all images were scored based on an MRI grading system (Grade I [normal brain parenchyma] to Grade
Asikainen, Bazarian, Bigler, Brain Trauma Foundation, Byrne, Chew, Englander, Firsching, Frey, Friedenberg, Hicks, Hilario, Kearsley-Fleet, Klein, Kornegay, Lagares, Lannsjö, Lee, Lowenstein, Löscher, Management of Concussion/mTBI Working Group, McDonald, Mittl, Orrison, Pearl, Platt, Sande, Schwartz-Porsche, Shenton, Shores, Simpson, Skandsen, Steinmetz, Tanoue, Vespa, Wendt-Hornickle, Wilde, Yuh, Zuercher   +38 more
core   +2 more sources