Results 81 to 90 of about 40,750 (280)

The Evidence Behind the Treatment of Canine Idiopathic Epilepsy [PDF]

, 2016
Oral phenobarbital and imepitoin in particular, followed by potassium bromide and levetiracetam are likely to be effective for the treatment of canine idiopathic epilepsy. There is strong evidence supporting the use of oral phenobarbital and imepitoin as
Brodbelt, D C, Charalambous, M, Volk, H A   +2 more
core   +3 more sources

Neonatal Seizures in Tuberous Sclerosis Complex: A Case Series

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Epilepsy affects up to 90% of patients with tuberous sclerosis complex (TSC); earlier seizure onset is associated with worse neurocognitive outcomes. The incidence of neonatal seizures in TSC is unknown, although in a recent multicenter trial 23% of infants with TSC were excluded prior to randomization because of pre‐existing ...
Kristina Jülich, Kristen Arredondo
wiley   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source

Newer drugs for focal epilepsy in adults [PDF]

, 2012
A 28 year old woman sees her general practitioner after experiencing what sounds like a convulsion without any apparent provoking factor. Over the past month she has also had “blank spells” during which her husband noticed her to be unresponsive.
Brodie, M., Kwan, P.
core   +1 more source

Real-World Evidence on Levetiracetam-Induced Hypokalemia: An Active Comparator Cohort Study

Drugs - Real World Outcomes
Background Levetiracetam is an anti-seizure medication (ASM) with an established safety profile. However, a potential safety signal of hypokalemia following levetiracetam use was published in the World Health Organization newsletter.
Ohoud Almadani, Raseel Alroba, Almaha Alfakhri, Sumaya Almohareb, Turki Althunian, Adel A. Alrwisan   +5 more
doaj   +1 more source

Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. [PDF]

, 2017
ObjectiveTo evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE).MethodsRats were treated with BRV (10 mg/kg) 10 min after ...
Alldredge, Biton, Brophy, Chen, Coeytaux, DeLorenzo, FDA, Gezalian, Gillard, Glauser, Griffin, Klein, Klein, Klein, Klitgaard, Klitgaard, Matagne, Matagne, Mazarati, Mazarati, Mazarati, Naylor, Nicolas, Reagan-Shaw, Ryvlin, Sanchez, Silbergleit, Stockis, Suchomelova, Treiman, Trinka, Wasterlain, Wood   +32 more
core   +1 more source

Antiepileptic drugs’ tolerability and safety – a systematic review and meta-analysis of adverse effects in dogs [PDF]

, 2016
Various anti-epileptic drugs (AEDs) are used for the management of idiopathic epilepsy (IE) in dogs. Their safety profile is an important consideration for regulatory bodies, owners and prescribing clinicians.
A Stabile, A-MOL-V Kiviranta, AA Shukralla, AE Chauvet, AK Cook, AS Nash, B Dayrell-Hart, B Mackay, C Rundfeldt, CL Gaskill, CL Gaskill, CR Hooijmans, D Moher, D Ruehlmann, D Schwartz-Porsche, D Schwartz-Porsche, David C. Brodbelt, DE Bevier, DJ Meyer, DJ Weiss, DJ Weiss, DJU Schwartz-Porsche, DM Boothe, DM Boothe, DM Conning, E Bersan, E Ernst, E Perucca, E Thrift, EM Poffenbarger, F Sturtevant, G Habock, G Jacobs, G Zaccara, G Zaccara, GC Farnbach, HA Volk, HE Baird-Heinz, Holger A. Volk, J Speciale, JA Berlin, JC Mathis, JF Summers, JG Cunningham, JH McGee, JH Rossmeisl, JK Aronson, JM Steiner, KR Dyer, L Aagaard, LAPA Nafe, LB Kantrowitz, LC Paull, LG Cuervo, LK Pearce, M Charalambous, M Govendir, M Jambroszyk, M Podell, M Raw, M Srivastava, MA Holmes, Marios Charalambous, MFD Steinberg, MH Litchfield, ML Miller, MM Aitken, N Andric, N Shaw, NA Boynosky, PA March, PB Muller, PM Henricks, PN Papanikolaou, PN Papanikolaou, R Bracchi, R Chou, RM Turner, RM Walker, S Daminet, S Derry, S Golder, S Golder, S Rieck, S Steinmetz, S Wieland, SA Kube, SA Moore, Sara K. Shivapour, SD Ross, SE Bunch, SE Bunch, SE Bunch, SE Bunch, SE Yohn, SF Foster, T Klopmann von, T Klopmann von, T Klopmann von, VJ Navarro, W Loscher, W Loscher, Y Chang, Y Heynold, YK Loke, YK Loke   +105 more
core   +3 more sources

Epilepsy characteristics in patients with muscle‐eye‐brain disease: A systematic review of electroclinical features

Epileptic Disorders, EarlyView.
Abstract Background and Objectives Muscle‐Eye‐Brain disease (MEB) is a dystroglycanopathy that belongs to the congenital muscular dystrophies. Central nervous system manifestations include congenital brain abnormalities, neurodevelopmental delay, and epilepsy, making it a rare but important cause of developmental and epileptic encephalopathy.
Stefania Kalampokini, Evripidis Pityrigkas, Eleni Liouta, Georgia Pepe, Vasiliki Poulidou, Martha Spilioti, Vasilios K. Kimiskidis   +6 more
wiley   +1 more source

Therapeutic Drug Monitoring and Methods of Quantitation for Carbamazepine [PDF]

, 2017
Carbamazepine is an early anticonvulsant still used today in the treatment of several forms of epilepsy. An active metabolite in the human body contributes to its pharmacological effect.
Ana Vlasceanu, Cristian Balalau, Cristian Tuchila, Cristina Pirvu, Daniela Baconi, Denisa Balalau, Miriana Stan, null null   +7 more
core   +4 more sources

Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy [PDF]

, 2018
Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease.
A Klang, A Pakozdy, A Pakozdy, A Pakozdy, A Pellegrini, AD Quesnel, Akos Pakozdy, AM Wahle, AS Sawchuk, C Bertolani, CR Hooijmans, CW Dewey, D Hasegawa, D Hughes, D Moher, D Schwartz-Porsche, D Schwartz-Porsche, DB Roye, DE Cuff, DL Zoran, DM Boothe, DM Brewer, G Zaccara, G Zaccara, GE Solomon, GH Guyatt, H Volk, Holger A. Volk, JA Berlin, JA Wada, JAD Gasper, JM Ducote, KE Finnerty, KS Bailey, KS Bailey, LR Barnard, M Charalambous, M Charalambous, M Lowrie, M Podell, MA Cautela, MA Holmes, Marios Charalambous, MB Carnes, MJ Baho, NM van Gelder, O Engel, P Boydell, PN Papanikolaou, R Chou, S Cizinauskas, S Schriefl, S Wagner, SA Center, SD Ross, SF Bhatti, SM Cochrane, SM Cochrane, Sofie F. M. Bhatti   +58 more
core   +3 more sources