Results 81 to 90 of about 12,531 (249)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background This study investigated whether levosimendan, an inotropic calcium sensitizer, when combined with moderate therapeutic hypothermia, may exert synergistic benefits on post–cardiac arrest myocardial dysfunction and improve outcomes.
Chih‐Hung Wang +4 more
doaj +1 more source
Levosimendan as a therapeutic strategy to prevent neuroinflammation after aneurysmal subarachnoid hemorrhage? [PDF]
, 2021 Stefan Wanderer +6 more
openalex +1 more source
ChemBioChem, Volume 26, Issue 18, September 18, 2025.This review explores pathological disulfide‐crosslinking as a key driver of amyloidogenic protein misfolding and aggregation. Oxidative and ER stress pathways contributing to disease progression are discussed and emerging therapeutic strategies targeting disulfide‐linked aggregates in neurodegenerative and systemic amyloid diseases are examined ...
Dong Min Kang +4 more
wiley +1 more source
Annals of Intensive Care, 2019 Background Few data are available on the impact of levosimendan in refractory cardiogenic shock patients undergoing peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). The aim of this study was to evaluate the impact of levosimendan on
Shamir Vally +10 more
doaj +1 more source
Brain and Behavior, Volume 15, Issue 9, September 2025.This study identified six potential druggable genes (CALCRL, KCNJ11, NEK3, THSD1, MMP12, and HSD17B12) associated with ischemic stroke risk using a systematic druggable genome‐wide Mendelian randomization analysis. ABSTRACT Background Ischemic stroke (IS) treatment remains a significant challenge.
Peng Zhang +3 more
wiley +1 more source
Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT
Efficacy and Mechanism Evaluation, 2018 Background: In septic shock, cardiovascular resuscitation using catecholamine vasopressors and inotropes is standard therapy, but catecholamines have important side effects.
Anthony C Gordon +15 more
doaj +1 more source
Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats
Toxicology Reports, 2019 We investigated the effect of levosimendan on cisplatin (Cis)-induced nephrotoxicity. Rats were divided into four groups (n = 6). The first and second groups received normal saline (control) and intraperitoneal (i.p.) cisplatin (6 mg/kg) on day 7 ...
Aly M. Abdelrahman +6 more
doaj +1 more source
Cardiac Calcitropes, Myotropes, and Mitotropes: JACC Review Topic of the Week. [PDF]
, 2019 The term "inotrope" is familiar and intimately connected with pharmaceuticals clinically used for treatment of low cardiac output with cardiogenic shock.
Adams, KF +7 more
core +2 more sources
Percutaneous mechanical circulatory support for acute right heart failure: A practical approach
ESC Heart Failure, Volume 12, Issue 4, Page 2652-2668, August 2025.This is an overview of percutaneous mechanical circulatory support options for acute right heart failure, illustrating key clinical scenarios, device types, and principles of tailored device selection based on haemodynamics and underlying pathology. Abstract Acute right heart failure (RHF) represents a critical entity with significant morbidity and ...
Mario Gramegna +18 more
wiley +1 more source
Levosimendan in Cardiac Surgery
Journal of Cardiothoracic and Vascular Anesthesia, 2005 Levosimendan is a new calcium sensitizer with inodilatory properties. There is growing clinical experience with levosimendan given to cardiac surgical patients. The aim of this report was to evaluate the effects of perioperative use of levosimendan in surgical patients with high perioperative risk, compromised left ventricular (LV) function, or ...
Harjola, V +2 more
openaire +2 more sources