Results 51 to 60 of about 845,922 (255)

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide.

PLoS Genetics, 2019
The lipopolysaccharide O-antigen structure expressed by the European Helicobacter pylori model strain G27 encompasses a trisaccharide, an intervening glucan-heptan and distal Lewis antigens that promote immune escape.
Hong Li, Michael Marceau, Tiandi Yang, Tingting Liao, Xiaoqiong Tang, Renwei Hu, Yan Xie, Hong Tang, Alfred Tay, Ying Shi, Yalin Shen, Tiankuo Yang, Xuenan Pi, Binit Lamichhane, Yong Luo, Aleksandra W Debowski, Hans-Olof Nilsson, Stuart M Haslam, Barbara Mulloy, Anne Dell, Keith A Stubbs, Barry J Marshall, Mohammed Benghezal   +22 more
doaj   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Infant Botulism and Carbohydrate Blood Group Antigens: Preliminary Results from a Discordant Twin Study

Journal of Pediatrics: Clinical Practice
Objective: We investigated if specific carbohydrate blood group antigens were associated with infant botulism (IB) among discordant twins and triplets.
Haydee A. Dabritz, PhD, Mayuri V. Panditrao, PhD, MPH, Suchitra Pandey, MD, Nir Dover, PhD, Jason R. Barash, CLS, MT(ASCP), Jessica M. Khouri, MD, Jennifer S. Read, MD, MS, MPH   +6 more
doaj   +1 more source

Glycan-dependent cell adhesion mechanism of Tc toxins

Nature Communications, 2020
Although Tc toxins are a major class of bacterial toxin translocation systems, little is known about their receptor binding. Here, the authors identify heparins/heparan sulfates and Lewis antigens as receptors for different Tc toxins, determine cryo-EM ...
Daniel Roderer, Felix Bröcker, Oleg Sitsel, Paulina Kaplonek, Franziska Leidreiter, Peter H. Seeberger, Stefan Raunser   +6 more
doaj   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Lewis antigen‑negative pancreatic cancer: An aggressive subgroup

International Journal of Oncology, 2020
Carbohydrate antigen 19‑9 (CA19‑9) is the most important biomarker for pancreatic cancer. Approximately 5‑10% of individuals are Lewis antigen negative with scarce secretion of CA19‑9 and fucosylation deficiency. However, the characteristics of Lewis‑negative pancreatic cancer are unidentified.
Liu, Chen, Deng, Shengming, Jin, Kaizhou, Gong, Yitao, Cheng, He, Fan, Zhiyao, Qian, Yunzhen, Huang, Qiuyi, Ni, Quanxing, Luo, Guopei, Yu, Xianjun   +10 more
openaire   +3 more sources

Complementary use of carbohydrate antigens lewis a, lewis b, and sialyl-lewis a (Ca19.9 epitope) in gastrointestinal cancers: Biological rationale towards a personalized clinical application [PDF]

, 2020
Carbohydrate antigen 19.9 (CA19.9) is used as a tumor marker for clinical and research purposes assuming that it is abundantly produced by gastrointestinal cancer cells due to a cancer-associated aberrant glycosylation favoring its synthesis. Recent data
Caretti A., Indellicato R., Trinchera M., Zulueta A., Rossella Indellicato, Anna Caretti, Marco Trinchera, Aida Zulueta   +7 more
core   +2 more sources

Invasive breast cancer in Argentine women: association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature

Breast Cancer: Targets and Therapy, 2011
Sandra O Demichelis, Marina T Isla-Larrain, Luciano Cermignani, Cecilio G Alberdi, Amada Segal-Eiras, María Virginia CroceCentre of Basic and Applied Immunological Research, Faculty of Medical Sciences, National University of La Plata, La ...
Croce MV, Segal-Eiras A, Alberdi CG, Cermignani L, Isla-Larrain MT, Demichelis SO   +5 more
doaj  

Norovirus Gastroenteritis Outbreak with a Secretor-independent Susceptibility Pattern, Sweden

Emerging Infectious Diseases, 2010
Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease.
Johan Nordgren, Elin Kindberg, Per-Eric Lindgren, Andreas Matussek, Lennart Svensson   +4 more
doaj   +1 more source

alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo. [PDF]

PLoS ONE, 2010
BACKGROUND: Cell surface sialylation is emerging as an important feature of cancer cell metastasis. Sialyltransferase expression has been reported to be altered in tumours and may account for the formation of sialylated tumour antigens.
Marta Pérez-Garay, Beatriz Arteta, Lluís Pagès, Rafael de Llorens, Carme de Bolòs, Fernando Vidal-Vanaclocha, Rosa Peracaula   +6 more
doaj   +1 more source