Results 71 to 80 of about 1,731,278 (307)

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo. [PDF]

PLoS ONE, 2010
BACKGROUND: Cell surface sialylation is emerging as an important feature of cancer cell metastasis. Sialyltransferase expression has been reported to be altered in tumours and may account for the formation of sialylated tumour antigens.
Marta Pérez-Garay, Beatriz Arteta, Lluís Pagès, Rafael de Llorens, Carme de Bolòs, Fernando Vidal-Vanaclocha, Rosa Peracaula   +6 more
doaj   +1 more source

Regulation of differentiation- and proliferation-inducers on Lewis antigens, α-fucosyltransferase and metastaticotential in hepatocarcinoma cells

British Journal of Cancer, 2001
The expressions of Lewis (Le) antigens, α-1,3/1,4 fucosyltransferases (α-1,3/1,4 FuTs), and metastatic potential after the treatment of 2 differentiation inducers, all-trans retinoic acid (ATRA), 8-bromo-cyclic 3′,5′adenosine monophosphate (8-Br-cAMP ...
F. Liu, H. Qi, H.-L. Chen
semanticscholar   +1 more source

Transferases reduced in h1299/CD82 cells (Expression levels of possible regulators of sialyl Lewis antigens analysed by DNA microarray).

, 2015
Transferases reduced in h1299/CD82 cells (Expression levels of possible regulators of sialyl Lewis antigens analysed by DNA microarray).
Tsuyoshi Sugiura (732081), Naoya Yoshihama (732073), Koujiro Yamaguchi (732074), Yosuke Kobayashi (732078), Yoshihide Mori (732080), Satomi Chigita (732075), Masakazu Abe (732077), Kotaro Ishii (308438), Naonari Akimoto (732079), Mariko Mine (732076)   +9 more
core   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Glycophenotype of prostatic carcinomas

Folia Histochemica et Cytobiologica, 2010
The factors that affect the progression of prostatic carcinoma are poorly understood, but it is known that carbohydrateantigens on the tumour cell surface play a role in the transforming and metastatic processes.
M.N. Khabaz, J. McClure, S. McClure, R.W. Stoddart   +3 more
doaj  

Lewis antigen‑negative pancreatic cancer: An aggressive subgroup

International Journal of Oncology, 2020
Carbohydrate antigen 19‑9 (CA19‑9) is the most important biomarker for pancreatic cancer. Approximately 5‑10% of individuals are Lewis antigen negative with scarce secretion of CA19‑9 and fucosylation deficiency. However, the characteristics of Lewis‑negative pancreatic cancer are unidentified.
Liu, Chen, Deng, Shengming, Jin, Kaizhou, Gong, Yitao, Cheng, He, Fan, Zhiyao, Qian, Yunzhen, Huang, Qiuyi, Ni, Quanxing, Luo, Guopei, Yu, Xianjun   +10 more
openaire   +3 more sources

Transferases increased in h1299/CD82 cells (Expression levels of possible regulators of sialyl Lewis antigens analysed by DNA microarray).

, 2015
Transferases increased in h1299/CD82 cells (Expression levels of possible regulators of sialyl Lewis antigens analysed by DNA microarray).
Tsuyoshi Sugiura (732081), Naoya Yoshihama (732073), Koujiro Yamaguchi (732074), Yosuke Kobayashi (732078), Yoshihide Mori (732080), Satomi Chigita (732075), Masakazu Abe (732077), Kotaro Ishii (308438), Naonari Akimoto (732079), Mariko Mine (732076)   +9 more
core   +1 more source

The Relationship of P1 and Lewis Antigens with Peritoneal Dialysis-Related Escherichia Coli Peritonitis

, 2011
It has been known that the P1 and Lewis antigens on red blood cells (RBCs ) affect the risk of Escherichia coli- related urinary tract infection. In the present study, we investigated the associations between those antigens and peritoneal dialysis (PD ...
丁羿文;高芷華;邱彥霖;羅仕錡;胡賦强;吳寬墩, TING, I-WEN;KAO, TZE-WAH;CHIU, YEN-LING;LO, SHYH-CHYI;HU, FU-CHANG;WU, KWAN-DUN   +1 more
core  

Rotavirus P[8] Infections in Persons with Secretor and Nonsecretor Phenotypes, Tunisia

Emerging Infectious Diseases, 2015
To determine whether rotavirus infections are linked to secretor status, we studied samples from children in Tunisia with gastroenteritis. We phenotyped saliva for human blood group antigens and tested feces for rotavirus.
Siwar Ayouni, Khira Sdiri-Loulizi, Alexis de Rougemont, Marie Estienney, Katia Ambert-Balay, Serge Aho, Sabeur Hamami, Mahjoub Aouni, Mohamed Neji-Guediche, Pierre Pothier, Gaël Belliot   +10 more
doaj   +1 more source