Results 91 to 100 of about 845,922 (255)

Synergistic Effects of Metal–Organic Nanoplatform and Guanine Quadruplex-Based CpG Oligodeoxynucleotides in Therapeutic Cancer Vaccines with Different Tumor Antigens

open access: yesVaccines
Oligodeoxynucleotides (ODNs) containing unmethylated cytosine–phosphate–guanosine (CpG) motifs are readily recognized by Toll-like receptor 9 on immune cells, trigger an immunomodulatory cascade, induce a Th1 -biased immune milieu, and have great ...
Xia Li   +4 more
doaj   +1 more source

The expression of ABH and Lewis antigens in Brazilian semi-isolated Black communities

open access: yesGenetics and Molecular Biology, 2002
The expression of the ABH and Lewis blood groups was determined in blood and saliva samples from two semi-isolated Black communities of Northern Brazil: Cametá and Alcântara.
Tereza Cristina OLiveira Corvelo   +2 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

open access: yesBritish Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu   +6 more
wiley   +1 more source

Structural diversity and biological importance of ABO, H, Lewis and secretor histo-blood group carbohydrates

open access: yesRevista Brasileira de Hematologia e Hemoterapia
ABO, H, secretor and Lewis histo-blood system genes control the expression of part of the carbohydrate repertoire present in areas of the body occupied by microorganisms.
Luiz Carlos de Mattos
doaj   +1 more source

Losses of expression of the antigens A, Lea and Lex and over-expression of Ley in carcinomas and HG-SIL of the uterine cervix

open access: yesDiagnostic Pathology, 2008
Background The glycosylation of a great number of molecules, glyco-protein or glycolipids, has been of interest for decades. Objective To compare the expressive patterns of the isoantigenic determinants of histo-blood groups ABH and Lewis in squamous and
Álvarez-Fernández Emilio   +1 more
doaj   +1 more source

CD93—An emerging vascular target in cancer therapy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira   +3 more
wiley   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

open access: yesClinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson   +6 more
wiley   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

open access: yesThe FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam   +4 more
wiley   +1 more source

Letter, Betty Carter to Lawrence Lewis, 1824 November 22

open access: yes
Betty Carter writes to her brother Lawrence Lewis at Woodlawn. She discusses illnesses in the family and Lafayette’s visit to Fredericksburg, Va., the tomb of Washington, and his meeting with Thomas Jefferson.
Carter, Betty Lewis, 1765-1830
core  

Interview with Arthur Lewis by Drew Lewis

open access: yes, 1930
Lewis tells about how his life was impacted by the Great Depression and the after effects of Pearl Harbor. Rationing and a more militaristic atmosphere became a daily occurrence and everyone was much more patriotic.
Lewis, Arthur
core  

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