Results 161 to 170 of about 80,492 (287)

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

Brain Pathology, EarlyView.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García, Jorge Mena, Carol‐Ann Lao, David Adamuz, Laura Arnaldo, Cristina Carrato, Alex Menendez, Daniela Samaniego, Dolores Vilas, Lourdes Ispierto, Anna Planas, Ramiro Alvarez, Pau Pastor, Katrin Beyer   +13 more
wiley   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, EarlyView.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

Parkinson's Disease and Salivary Issues: A Survey

Gerodontology, EarlyView.
ABSTRACT Background Salivary dysfunction, including xerostomia and drooling, is common in Parkinson's disease and further impairs oral health and quality of life, which are already compromised in this population. Their effective management demands deeper insight into the complexity of salivary dysfunction.
Beau D. M. van Dijk, Merel C. Verhoeff, Niels van der Aa, Frank Lobbezoo   +3 more
wiley   +1 more source

General Dementia Training for the Social Care Workforce: A Systematic Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim The aim of this systematic review was to assess and synthesize the global evidence on existing general dementia training and education for the social care workforce. Design Mixed‐methods systematic review. Data Sources Systematic searches on five databases (PubMed, APA PsychINFO, CINAHL Plus, Scopus, Web of Science) were conducted for ...
Clarissa Giebel, Thais Caprioli, Marie Poole, Catherine Talbot, Jacqui Cannon, Kerry Hanna, Louise Robinson, Deborah Rozansky, Hilary Tetlow, Madeleine Walpert, Mark Gabbay   +10 more
wiley   +1 more source

Comparing phenotypic features between Parkinson's disease dementia and dementia with Lewy bodies. [PDF]

J Neurol
Gunawardana CW, Burke PGR, Ignatavicius A, Matar E, Lewis SJG.   +4 more
europepmc   +1 more source

Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus

Journal of Neuropsychology, EarlyView.
Abstract This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM‐related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease ...
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N. Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta   +9 more
wiley   +1 more source

Associations between apathy and global cognition in a 5‐year follow‐up of individuals with Alzheimer's disease

Journal of Neuropsychology, EarlyView.
Abstract Apathy is a common neuropsychiatric symptom in Alzheimer's disease (AD) associated with cognitive and functional impairment. Longitudinal studies have examined the associations between apathy and cognition in AD and other dementias, but more information is needed to understand whether the relationships are consistent longitudinally, and ...
Henna‐Riikka Loukola, Maikki Kärkkäinen, Tuomas Selander, Kirsi Honkalampi, Anne M. Koivisto, Toni T. Saari   +5 more
wiley   +1 more source

Increased intervals in enzyme replacement therapy for stable type 1 Gaucher disease: A non‐inferiority sequential trial emulation

Journal of Internal Medicine, EarlyView.
Abstract Objective To compare the efficacy and safety of extended interval (Q3–4W) enzyme replacement therapy (ERT) versus standard biweekly (Q2W) ERT in clinically stable type 1 Gaucher disease (GD) patients. Methods We emulated a target trial with a sequential trial design, using data from the French Gaucher Disease Registry.
Maxime Beydon, Jérôme Stirnemann, Karima Yousfi, Samira Zebiche, Dalil Hamroun, Anaïs Brassier, Samia Pichard, Laure Swiader, Thierry Billette de Villemeur, Bénédicte Héron, Florence Dalbies, Bérengère Cador, Anne‐Sophie Guemann, Francis Gaches, Bénédicte Hivert, Vanessa Leguy‐Seguin, Agathe Masseau, Yves‐Marie Pers, Magali Pettazzoni, Soumeya Bekri, Catherine Caillaud, Edouard Le Guillou, Marie Szymanowski, Leonardo Astudillo, Wladimir Mauhin, Yann Nadjar, Christine Serratrice, Marc G. Berger, Fabrice Camou, Nadia Belmatoug, Yann Nguyen, the French Evaluation of Gaucher Disease Treatment Committee   +31 more
wiley   +1 more source

Assessing the Adaptive/Maladaptive Strategies of Mastication in Older Taiwanese Individuals Using the Masticatory Adaptation Experience Questionnaire (MAEQ)

Journal of Oral Rehabilitation, EarlyView.
The study aims to establish the Masticatory Adaptation Experience Questionnaire (MAEQ) and investigate age‐related factors of masticatory adaptation. ABSTRACT Background There are various tests to assess the individual performance of mastication. However, it has remained unknown how individuals used adaptive (e.g., ‘increasing time to chew’) and ...
Chia‐Shu Lin, Ta‐Chung Chen, Yi‐Chen Chen, Li‐Jung Chao, Wei‐Chieh Kao, Jong‐Ling Fuh   +5 more
wiley   +1 more source

Locus coeruleus alterations in dementia with Lewy bodies: A systematic review. [PDF]

Alzheimers Dement (N Y)
Bain A, Tomeo C, André C, Garnier-Crussard A, de Flores R, Dautricourt S.   +5 more
europepmc   +1 more source