Results 261 to 270 of about 91,122 (346)

Heat shock protein 10 as a chaperone modulating α‐synuclein amyloid fibril formation

Protein Science, Volume 35, Issue 2, February 2026.
Abstract HSP10 is a well‐known human co‐chaperone that interacts with HSP60 to comprise the HSP60/10 chaperonin complex which upholds mitochondrial proteostasis. HSP10 also demonstrates independent roles in binding to misfolded proteins and interacts with several amyloidogenic client proteins.
Johan N. K. Larsson, Ranjeet Kumar, Fiamma Ayelen Buratti, Sofie Nyström, Pernilla Wittung‐Stafshede, Per Hammarström   +5 more
wiley   +1 more source

Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of Dementia With Lewy Bodies in Men [PDF]

Alexander Hart, Georgina M. Aldridge, Qiang Zhang, Nandakumar S. Narayanan, Jacob E. Simmering   +4 more
openalex   +1 more source

Does Platelet Transcriptome Dysregulation Across the Lewy Body Continuum Mirror Neuronal Dysfunction? [PDF]

Int J Mol Sci
Arnaldo L, Mena J, Adamuz D, Menéndez A, Serradell M, Samaniego D, Gaig C, Ispierto L, Vilas D, Iranzo A, Aarsland D, Pastor P, Beyer K.   +12 more
europepmc   +1 more source

Concentration‐dependent mutational scanning probes the cellular folding landscape of α‐synuclein in yeast

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The misfolding and aggregation of α‐synuclein is a central molecular event in the etiology of Parkinson's disease and related disorders. α‐synuclein misfolding and pathology are both concentration‐dependent, but it is not clear precisely how changes in concentration alter the folding landscape within cells. Whereas most conventional structural
Daeun Noh, Robert W. Newberry
wiley   +1 more source

FloodUnet: A Rapid Spatio‐Temporal Prediction Model for Flood Evolution Based on an Enhanced U‐Net

Water Resources Research, Volume 62, Issue 2, February 2026.
Abstract Flooding causes significant loss of life and economic damage and affects healthy development of society. Deep learning (DL) models demonstrate significant advantages in improving computational efficiency while maintaining accuracy. Existing research of predicting dynamic flood evolution still remains some gaps for predicting flooding maps from
T. Chen, J. Tian, J. Sun, Z. Zhang, H. Chai, B. Lin, X. Fu   +6 more
wiley   +1 more source

Identification of expanded and interrupted ATXN2 repeat expansions in Parkinson's disease and Lewy Body Dementia cohorts. [PDF]

NPJ Parkinsons Dis
Wang L, Milton M, Fearnley LG, Bhalala OG, Bahlo M, Rafehi H.   +5 more
europepmc   +1 more source

Clinical Validation of α‐Synuclein in Salivary Extracellular Vesicles as a Biomarker for Parkinson's Disease: A Longitudinal Study

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Salivary Extracellular vesicles (SEVs) isolated from PD patients exhibit increased levels of both total (α‐SynTot) and oligomeric alpha‐synuclein (α‐SynOlig). In PD patients, SEVS‐α‐SynOlig levels correlate with cognitive decline (MMSE) and motor fluctuations (MDS‐UPDRS IV) and remain stable after 1 year follow‐up.
Antonia Gurgone, Vita Cardinale, Marta M. Tangari, Serena Budicin, Debora Comai, Claudia Ledda, Leonardo Lopiano, Giovanni Camussi, Maurizio Zibetti, Maurizio Giustetto   +9 more
wiley   +1 more source