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Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings [PDF]

Alzheimer’s Research & Therapy, 2019
The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator’s meeting was held on December 14, 2017, in New Orleans.
Bethany Peterson, Melissa Armstrong, Douglas Galasko, James E. Galvin, Jennifer Goldman, David Irwin, Henry Paulson, Daniel Kaufer, James Leverenz, Angela Lunde, Ian G. McKeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matt Barrett, Kimiko Domoto-Reilly, John Duda, Stephen Gomperts, Neill Graff-Radford, Samantha Holden, Lawrence Honig, Daniel Huddleston, Carol Lippa, Irene Litvan, Carol Manning, Karen Marder, Charbel Moussa, Chiadi Onyike, Fernando Pagan, Alexander Pantelyat, Victoria Pelak, Kathleen Poston, Joseph Quinn, Irene Richard, Liana S. Rosenthal, Marwan Sabbagh, Douglas Scharre, Sharon Sha, Holly Shill, Yasar Torres-Yaghi, Tina Christie, Todd Graham, Ian Richards, Mike Koehler, Brad Boeve   +44 more
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Lewy Body Dementia [PDF]

Clinics in Geriatric Medicine, 2018
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia following Alzheimer disease. It stems from the formation of Lewy bodies, which contain aggregates of the misfolded protein, α-synuclein. These deposit in areas of the nervous system and brain, leading to neuronal cell death and causing clinically apparent symptoms ...
Ansello, Edward F.
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Cortical Lewy Body Dementia [PDF]

Behavioural Neurology, 1990
In cortical Lewy body dementia the distribution of Lewy bodies in the nervous system follows that of Parkinson's disease, except for their greater profusion in the cerebral cortex. The cortical tangles and plaques of Alzheimer pathology are often present,
W. R. G. Gibb
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Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population‐based sample [PDF]

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2017
Introduction Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal Olmsted County ...
Youngsin Jung, Brendon P. Boot, Michelle M. Mielke, Tanis J. Ferman, Yonas E. Geda, Eric McDade, Teresa J.H. Christianson, David S. Knopman, Erik K. St Louis, Michael H. Silber, Ronald C. Petersen, Bradley F. Boeve   +11 more
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Evidence for divergent cortical organisation in Parkinson’s disease and Lewy Body Dementia [PDF]

Nature Communications
Dementia is a defining feature of Lewy body disease: its timing and onset distinguish different clinical diagnoses, and its effect on quality of life is profound.
Angeliki Zarkali, George Thomas, Naomi Hannaway, Ivelina Dobreva, Melissa Grant Peters, Martina F. Callaghan, Mina Ryten, Rimona S. Weil   +7 more
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Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies [PDF]

Molecular Neurodegeneration
Lewy body dementia is the second most common form of neurodegenerative dementia, following Alzheimer’s disease. This umbrella term encompasses dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD).
Hiroaki Sekiya, Tomoyasu Matsubara, Michael A. DeTure, Dennis W. Dickson   +3 more
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Clinical prevalence of Lewy body dementia [PDF]

Alzheimer’s Research & Therapy, 2018
Background The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studies vary greatly.
Joseph P. M. Kane, Ajenthan Surendranathan, Allison Bentley, Sally A. H. Barker, John-Paul Taylor, Alan J. Thomas, Louise M. Allan, Richard J. McNally, Peter W. James, Ian G. McKeith, David J. Burn, John T. O’Brien   +11 more
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Research models to study lewy body dementia [PDF]

Molecular Neurodegeneration
Lewy body dementia (LBD) encompasses neurodegenerative dementias characterized by cognitive fluctuations, visual hallucinations, and parkinsonism. Clinical differentiation of LBD from Alzheimer’s disease (AD) remains complex due to symptom overlap, yet ...
Suelen Lucio Boschen, Aarushi A. Mukerjee, Ayman H. Faroqi, Ben E. Rabichow, John Fryer   +4 more
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Dementia with Lewy bodies [PDF]

Psychiatry, 1999
Objective: The aim of this paper is to summarise recent clinical and research findings with regard to dementia with Lewy bodies (DLB). Method: A literature review (Medline) was carried out, as well as a review of reports of recent DLB symposia of international meetings and of other relevant papers and data known to the authors.
I, McKeith, J, O'Brien
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Novel Ubiquitin Specific Protease-13 Inhibitors Alleviate Neurodegenerative Pathology

Metabolites, 2021
Ubiquitin Specific Protease-13 (USP13) promotes protein de-ubiquitination and is poorly understood in neurodegeneration. USP13 is upregulated in Alzheimer’s disease (AD) and Parkinson’s disease (PD), and USP13 knockdown via shRNA reduces neurotoxic ...
Xiaoguang Liu, Kaluvu Balaraman, Ciarán C. Lynch, Michaeline Hebron, Christian Wolf, Charbel Moussa   +5 more
doaj   +1 more source