Results 101 to 110 of about 169 (166)

Assessing the Adaptive/Maladaptive Strategies of Mastication in Older Taiwanese Individuals Using the Masticatory Adaptation Experience Questionnaire (MAEQ)

Journal of Oral Rehabilitation, Volume 53, Issue 7, Page 1306-1318, July 2026.
The study aims to establish the Masticatory Adaptation Experience Questionnaire (MAEQ) and investigate age‐related factors of masticatory adaptation. ABSTRACT Background There are various tests to assess the individual performance of mastication. However, it has remained unknown how individuals used adaptive (e.g., ‘increasing time to chew’) and ...
Chia‐Shu Lin, Ta‐Chung Chen, Yi‐Chen Chen, Li‐Jung Chao, Wei‐Chieh Kao, Jong‐Ling Fuh   +5 more
wiley   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, Volume 15, Issue 22, 12 June 2026.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Cognitive Trajectories from Preclinical Alzheimer's Disease to Dementia

Advanced Science, Volume 13, Issue 32, 9 June 2026.
A continuous, multi‐domain characterization of cognitive decline across the Alzheimer's disease spectrum identifies when individual cognitive measures become abnormal. Episodic memory declines first, followed by executive function, language, processing speed, and visuospatial abilities, supporting improved clinical interpretation and optimized endpoint
Fredrik Öhman, Lars Lau Raket, Michael Schöll, for the Alzheimer's Disease Neuroimaging Initiative†   +3 more
wiley   +1 more source

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, Volume 13, Issue 33, 15 June 2026.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

Factors linked to informal caregiver burden in dementia across Latin America and the Caribbean: A systematic review and meta‐analysis

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Informal caregivers are central to dementia care in Latin America and the Caribbean (LAC), yet determinants of caregiver burden remain insufficiently characterized. We conducted a systematic review and meta‐analysis of studies examining patient‐ and caregiver‐related correlates of burden in LAC.
Paula Quintero‐Cardona, María Alejandra Tangarife, John Blandon, Juan Carlos Arango‐Lasprilla, Agustin Ibanez, Sandra Baez   +5 more
wiley   +1 more source

Provider and patient perspectives on the diagnosis and treatment of Alzheimer's disease: A global perspective from the Global Alzheimer's Leadership Series (GoALS)

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Since 2016, the Alzheimer's Association and the Fondation Alzheimer have hosted Global Alzheimer's Leadership Series (GoALS) global think tanks, with world‐leading experts for innovative discussions to advance Alzheimer's disease (AD) research and care.
Philippe Amouyel, Sandrine Andrieu, Angela Bradshaw, Ralph C. Carmona, Magali Dumont, Lea Tenenholz Grinberg, Takeshi Iwatsubo, Oskar Hansson, Clifford R Jack Jr, Gregory A Jicha, Simin Mahinrad, Eric McDade, Catherine J Mummery, Ronald C Petersen, Shelagh Robinson, Julie A. Schneider, Lenny Shellcross, Amanda G Smith, Heather M. Snyder, Beth Tapply, Charlotte Teunissen, Wiesje M. van der Flier, Bruno Vellas, David Wallon, Jeff D Williamson, Donna Wilcock, Maria C. Carrillo   +26 more
wiley   +1 more source

Cerebral small vessel disease and cognition in older adults across the neurodegenerative spectrum: insights from the COMPASS‐ND study

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Imaging‐based cerebral small vessel disease (CSVD) summary scores quantify CSVD burden. This study characterized CSVD scores and assessed their cognitive associations in older adults with various neurodegenerative diseases and cognitive profiles.
Dylan X. Guan, Zahinoor Ismail, Graham A. McLeod, Shahab Marzoughi, Eric E. Smith, Aravind Ganesh   +5 more
wiley   +1 more source