Results 51 to 60 of about 41,299 (161)

LEWY BODY VARIANT OF ALZHEIMER DISEASE

Zdravniški Vestnik, 2003
Background. Clinicopathological studies indicate that Alzheimer’s disease (AD) is the most common neurodegenerative cause of dementia, the other frequent causes are AD combined with diffuse Lewy bodies and dementia with Lewy bodies (DLB) by itself.
Jera Jeruc, Aleš Kogoj, Marko Pišljar, Mara Popović   +3 more
doaj  

Sex differences for clinical correlates of substantia nigra neuron loss in people with Lewy body pathology

Biology of Sex Differences
Background Lewy body dementia (LBD) phenotype is associated with the presence and degree of Lewy body, Alzheimer’s pathologies, and substantia nigra neuron loss.
Ece Bayram, David G. Coughlin, Ravi Rajmohan, Irene Litvan   +3 more
doaj   +1 more source

Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson’s disease

PLoS Pathogens, 2021
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. PD is pathologically characterized by the death of midbrain dopaminergic neurons and the accumulation of intracellular protein inclusions called Lewy bodies or Lewy neurites ...
Soo Jin Park, Uram Jin, Sang Myun Park
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Frederic Lewy: how the two World Wars changed his life, work, and name

Arquivos de Neuro-Psiquiatria
In 1912, Friedrich Lewy described the inclusion bodies present in Parkinson disease and in Lewy body dementia. Throughout his life, Lewy fought in two wars – on opposite sides.
Patrick Emanuell Mesquita Sousa-Santos, Pedro Machry Pozzobon, Igor de Lima e Teixeira   +2 more
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A 100-year history of dementia with Lewy bodies

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
It takes more than one hundred years to understand dementia with Lewy bodies (DLB). Frederick Henry Lewy, a Germany doctor who studied the neuropathology of Parkinson's disease (PD) at Munich University, described eosinophilic intracytoplasmic inclusions
Wei YUE, Yong JI
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Expression of α ⁃synuclein in the spinal cord of Alzheimer's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2010
Objective To investigate the characteristics of α⁃synucleinopathy in the spinal cord of patients with Alzheimer's disease (AD). Methods HE staining and immunohistochemistry staining were used to determine the expression of α⁃synuclein in the spinal cord (
Yan⁃jun GUO, Lu⁃ning WANG, Ming⁃wei ZHU, Hong⁃hong ZHANG, Ya⁃zhuo HU, Zhi⁃tao HAN, Wei⁃qin ZHAO, De⁃xin WANG   +7 more
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Spatial multi-omics identifies early synaptic pruning and context-specific dopaminergic vulnerability in synucleinopathies

Nature Communications
Parkinson’s disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta, but the molecular events preceding neuronal loss remain unclear.
Svenja-Lotta Rumpf, Felix L. Strübing, Karsten Nalbach, Claudia Marina Vargiu, Giacomo Berg, Stefan F. Lichtenthaler, Piero Parchi, Pan Gao, Weilin Chen, Matthias Brendel, Johannes S. Gnörich, Alexander Bernhardt, Léa Dias Rodrigues, Günter U. Höglinger, Jochen Herms, Thomas Koeglsperger   +15 more
doaj   +1 more source

Reply: Matters Arising ‘Lewy body disease or diseases with Lewy bodies?’

npj Parkinson's Disease, 2022
Kateřina Menšíková, Radoslav Matěj, Carlo Colosimo, Raymond Rosales, Lucie Tučková, Jiří Ehrmann, Dominik Hraboš, Kristýna Kolaříková, Radek Vodička, Radek Vrtěl, Martin Procházka, Martin Nevrlý, Michaela Kaiserová, Sandra Kurčová, Pavel Otruba, Petr Kaňovský   +15 more
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Prediction of Co-Occurrence of Lewy Body Disease with Alzheimer’s Disease

Journal of Alzheimer's Disease Reports
Identifying the coexistence of Lewy body (LB) pathology with Alzheimer’s disease (AD) in clinical practice is important in the era of anti-amyloid-β antibody therapy. However, few studies have predicted the presence of comorbid LB pathology with AD using
Kenichi Hashiguchi, Ryota Kobayashi, Daichi Morioka, Shinobu Kawakatsu, Kazutaka Sakamoto, Hiroshi Matsuda, Akihito Suzuki   +6 more
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Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Nature Communications
Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology.
Sophie E. Mastenbroek, Jacob W. Vogel, Lyduine E. Collij, Geidy E. Serrano, Cécilia Tremblay, Alexandra L. Young, Richard A. Arce, Holly A. Shill, Erika D. Driver-Dunckley, Shyamal H. Mehta, Christine M. Belden, Alireza Atri, Parichita Choudhury, Frederik Barkhof, Charles H. Adler, Rik Ossenkoppele, Thomas G. Beach, Oskar Hansson   +17 more
doaj   +1 more source