Results 31 to 40 of about 41,299 (161)

Neuropathology of incidental Lewy body & prodromal Parkinson’s disease

Molecular Neurodegeneration, 2023
Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there is currently no disease-modifying treatment to halt neuronal loss in PD.
Thomas Koeglsperger, Svenja-Lotta Rumpf, Patricia Schließer, Felix L. Struebing, Matthias Brendel, Johannes Levin, Claudia Trenkwalder, Günter U. Höglinger, Jochen Herms   +8 more
doaj   +1 more source

Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein

Neuropsychopharmacology Reports, 2018
Aim We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater
Masayo Fujita, Yoko Hagino, Yukio Takamatsu, Yuka Shimizu, Yoshiki Takamatsu, Kazutaka Ikeda, Makoto Hashimoto   +6 more
doaj   +1 more source

Characteristics of facial expression recognition ability in patients with Lewy body disease

Environmental Health and Preventive Medicine, 2018
Background The facial expression of medical staff has been known to greatly affect the psychological state of patients, making them feel uneasy or conversely, cheering them up. By clarifying the characteristics of facial expression recognition ability in
Yuriko Kojima, Tomohiro Kumagai, Tomoo Hidaka, Takeyasu Kakamu, Shota Endo, Yayoi Mori, Tadashi Tsukamoto, Takashi Sakamoto, Miho Murata, Takehito Hayakawa, Tetsuhito Fukushima   +10 more
doaj   +1 more source

Molecular Pathology of Lewy Body Diseases [PDF]

International Journal of Molecular Sciences, 2009
Lewy body diseases are characterized by the presence of Lewy bodies, alpha-synuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in these diseases.
Beyer, Katrin, Domingo-Sàbat, Montse, Ariza Fernández, A   +2 more
openaire   +3 more sources

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

Molecular Neurodegeneration, 2009
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major component of the Lewy body, the mechanisms by which neurons
Perry George, Castellani Rudy J, Takeda Atsushi, Choi Raymond, Kondo Eisaku, Siedlak Sandra L, Chen Shu G, Wang Xinglong, Liu Haihua, Su Bo, Smith Mark A, Zhu Xiongwei, Lee Hyoung-gon   +12 more
doaj   +1 more source

Structural connectivity networks in Alzheimer’s disease and Lewy body disease

Brain and Behavior, 2021
Objective We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies.
Kyoungwon Baik, Jin‐Ju Yang, Jin Ho Jung, Yang Hyun Lee, Seok Jong Chung, Han Soo Yoo, Young H. Sohn, Phil Hyu Lee, Jong‐Min Lee, Byoung Seok Ye   +9 more
doaj   +1 more source

Cortical Lewy Body Dementia

Behavioural Neurology, 1990
In cortical Lewy body dementia the distribution of Lewy bodies in the nervous system follows that of Parkinson's disease, except for their greater profusion in the cerebral cortex. The cortical tangles and plaques of Alzheimer pathology are often present,
W. R. G. Gibb
doaj   +1 more source

Listening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023
The regulatory path for drug approval is increasingly well defined. Drugs for the treatment of Alzheimer disease (AD) need to show statistically significant benefit over placebo with respect to cognitive and functional measures, with the Clinical ...
Marwan N. Sabbagh, Angela Taylor, Douglas Galasko, James E. Galvin, Jennifer G. Goldman, James B. Leverenz, Kathleen L. Poston, Bradley F. Boeve, David J. Irwin, Joseph F. Quinn   +9 more
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Intraneuronal Lewy body inclusions in Parkinson and diffuse Lewy body disease [PDF]

Journal of Cellular and Molecular Medicine, 2001
Keywords: Parkinson's disease; Lewy body disease; Lewy body inclusions; ubiquitin; α ...
openaire   +2 more sources

Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies

Molecular Neurodegeneration
Lewy body dementia is the second most common form of neurodegenerative dementia, following Alzheimer’s disease. This umbrella term encompasses dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD).
Hiroaki Sekiya, Tomoyasu Matsubara, Michael A. DeTure, Dennis W. Dickson   +3 more
doaj   +1 more source