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Diffuse Lewy body disease [PDF]
Diffuse Lewy body disease, also called dementia with Lewy bodies (DLB), is defined as progressive dementia and pathological Lewy bodies distributed in the central and autonomic nervous systems. The clinical features are dementia, cognitive fluctuations, visual hallucinations, parkinsonism, and REM sleep behavior disorder (RBD).
Yu Wei Lin, Daniel Truong
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In cortical Lewy body dementia the distribution of Lewy bodies in the nervous system follows that of Parkinson's disease, except for their greater profusion in the cerebral cortex. The cortical tangles and plaques of Alzheimer pathology are often present,
W. R. G. Gibb
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LEWY BODY VARIANT OF ALZHEIMER DISEASE [PDF]
Background. Clinicopathological studies indicate that Alzheimer’s disease (AD) is the most common neurodegenerative cause of dementia, the other frequent causes are AD combined with diffuse Lewy bodies and dementia with Lewy bodies (DLB) by itself.
Jera Jeruc +3 more
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A clinicopathological investigation of brainstem nuclei in Lewy body dementia [PDF]
Introduction: Lewy Body Dementias (LBD) - Dementia with Lewy Bodies (DLB) and Parkinson’s Disease Dementia (PDD) - are clinical diagnoses based on the one-year rule and varied symptom onset. Previously, degeneration of the locus coeruleus (LC) and dorsal
Patel, Shivani
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Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium
The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLBs) and ...
Gregory D. Scott +54 more
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The Alzheimer variant of Lewy body disease: A pathologically confirmed case-control study [PDF]
The objective of the study was to identify clinical features that distinguish patients with dementia with Lewy bodies (DLB), who were classified as Alzheimer's disease ( AD) patients, from patients with AD.
Müller, U. +9 more
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False memories in Lewy‐body disease [PDF]
Recently, de Boysson, Belleville, Phillips et al. (2011) found that patients with Lewy‐body disease (LBD) showed significantly lower rates of false memories than healthy controls, using the Deese–Roediger–McDermott (DRM) experimental procedure. Given that this result could be explained by the practically null rate of true recognition in the LBD group ...
Salvador Algarabel +4 more
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Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Gelpi, Ellen +30 more
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Tau protein, A beta 42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies [PDF]
The intra vitam diagnosis of dementia with Lewy bodies (DLB) is still based on clinical grounds. So far no technical investigations have been available to support this diagnosis.
Cepek, L. +23 more
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Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile +70 more
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