Results 21 to 30 of about 41,299 (161)

α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies

npj Parkinson's Disease, 2023
There is increasing interest in studying retinal biomarkers for various neurodegenerative diseases. Specific protein aggregates associated with neurodegenerative diseases are present in the retina and could be visualised in a non-invasive way. This study
Frederique J. Hart de Ruyter, Tjado H. J. Morrema, Jurre den Haan, Gina Gase, Jos W. R. Twisk, Johannes F. de Boer, Philip Scheltens, Femke H. Bouwman, Frank D. Verbraak, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans   +10 more
doaj   +1 more source

Lewy body disease and dementia with Lewy bodies

Proceedings of the Japan Academy, Series B, 2014
In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term "Lewy body disease" (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type and a diffuse type.
openaire   +3 more sources

Parkin Localizes to the Lewy Bodies of Parkinson Disease and Dementia with Lewy Bodies [PDF]

The American Journal of Pathology, 2002
Mutations in alpha-synuclein (alpha S) and parkin cause heritable forms of Parkinson disease (PD). We hypothesized that neuronal parkin, a known E3 ubiquitin ligase, facilitates the formation of Lewy bodies (LBs), a pathological hallmark of PD. Here, we report that affinity-purified parkin antibodies labeled classical LBs in substantia nigra sections ...
Michael G, Schlossmacher, Matthew P, Frosch, Wei Ping, Gai, Miguel, Medina, Nutan, Sharma, Lysia, Forno, Tomoyo, Ochiishi, Hideki, Shimura, Ronit, Sharon, Nobutaka, Hattori, J William, Langston, Yoshikuni, Mizuno, Bradley T, Hyman, Dennis J, Selkoe, Kenneth S, Kosik   +14 more
openaire   +2 more sources

Diffuse Lewy body disease

Neuropathology, 1998
Diffuse Lewy body disease (DLBD) has been studied from various viewpoints and, although clinical diagnostic criteria for DLBD have been proposed, diagnosis remains difficult. DLBD has been reported to be the second most common form of dementia in the aged, following Alzheimer‐type dementia. It has, however, been clinically under‐diagnosed.
openaire   +6 more sources

Fabry Disease With Concomitant Lewy Body Disease [PDF]

Journal of Neuropathology & Experimental Neurology, 2019
Abstract Although Gaucher disease can be accompanied by Lewy pathology (LP) and extrapyramidal symptoms, it is unknown if LP exists in Fabry disease (FD), another progressive multisystem lysosomal storage disorder. We aimed to elucidate the distribution patterns of FD-related inclusions and LP in the brain of a 58-year-old cognitively ...
Del Tredici, Kelly, Ludolph, Albert C, Feldengut, Simone, Jacob, Christian, Reichmann, Heinz, Bohl, Jürgen R, Braak, Heiko   +6 more
openaire   +3 more sources

Parkinson’s Disease and Dementia with Lewy Bodies: One and the Same

Journal of Parkinson’s Disease
The question whether Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are expressions of the same underlying disease has been vigorously debated for decades.
Per Borghammer, Niels Okkels, Daniel Weintraub   +2 more
doaj   +1 more source

Environmental risk factors provoke new thinking for prevention and treatment of dementia with Lewy bodies

Heliyon
In recent years, environmental factors have received attention in the pathogenesis of neurodegenerative diseases. Other than genetic factors, the identification of environmental factors and modifiable risk factors may create opportunities to delay the ...
Dinghao An, Yun Xu
doaj   +1 more source

Clinical biomarkers for Lewy body diseases

Cell & Bioscience, 2023
AbstractSynucleinopathies are a group of neurodegenerative disorders characterized by pathologic aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy neurites, and cytoplasmic inclusions in both neurons and glia. Two major classes of synucleinopathies are LB disease and multiple system atrophy.
Mai M. Abdelmoaty, Eugene Lu, Rana Kadry, Emma G. Foster, Shaurav Bhattarai, R. Lee Mosley, Howard E. Gendelman   +6 more
openaire   +3 more sources

Challenges and opportunities for improving the landscape for Lewy body dementia clinical trials

Alzheimer’s Research & Therapy, 2020
Lewy body dementia (LBD), including dementia with Lewy bodies and Parkinson’s disease dementia, affects over a million people in the USA and has a substantial impact on patients, caregivers, and society.
Jennifer G. Goldman, Leah K. Forsberg, Bradley F. Boeve, Melissa J. Armstrong, David J. Irwin, Tanis J. Ferman, Doug Galasko, James E. Galvin, Daniel Kaufer, James Leverenz, Carol F. Lippa, Karen Marder, Victor Abler, Kevin Biglan, Michael Irizarry, Bill Keller, Leanne Munsie, Masaki Nakagawa, Angela Taylor, Todd Graham   +19 more
doaj   +1 more source

Lewy body diseases and the gut

Molecular Neurodegeneration
Abstract Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since the initial descriptions of patients by James Parkinson. Recent experimental and human observational studies raise the possibility that pathogenic alpha-synuclein (⍺-syn) might develop in the GI tract and subsequently spread to susceptible brain ...
Timothy R. Sampson, Malú Gámez Tansey, Andrew B. West, Rodger A. Liddle   +3 more
openaire   +3 more sources