The effects of testicular aging on Leydig cells and the application of stem cells in restoring Leydig cells function [PDF]
Reproductive Biology and EndocrinologyWith the global population aging at an accelerated pace, testicular aging and its associated male health issues have garnered increasing attention. Testicular aging encompasses both age-related physiological decline and premature or pathological aging ...
Wen-bo Zhu +4 more
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Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells. [PDF]
PLoS ONE, 2013 Development of the testis begins with the expression of the SRY gene in pre-Sertoli cells. Soon after, testis cords containing Sertoli and germ cells are formed and fetal Leydig cells subsequently develop in the interstitial space. Studies using knockout
Kanako Miyabayashi +7 more
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Fetal Leydig cells in buffalo testis: Light and electron microscopic study
Indian Journal of Animal Sciences, 2020 The present study was conducted on testis of 20 buffalo fetuses ranging from 2.5 cm to 20 cm curved crown rump length (CVRL). The tissues were processed for light and transmission electron microscopic study.
INDERPREET SINGH +4 more
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Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone
Frontiers in Endocrinology, 2023 IntroductionAge-related decline in testosterone is associated with Leydig cell aging with impaired testosterone synthesis in aging. Obesity accelerates the age-related decline in testosterone.
Dandan Luo +10 more
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Isolation of Primary Leydig Cells from Murine Testis
Bio-Protocol, 2021 In males, Leydig cells are the primary source of testosterone, which is necessary for testis development, masculinization, and spermatogenesis. Leydig cells are a valuable cellular model for basic research; thus, it is important to develop an improved ...
Jinlian Liang +8 more
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Role of antioxidant to protect Leydig cells induced by reactive oxygen species: a literature review
Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2021 The Leydig cells play crucial role in steroidogenesis and spermatogenesis. Those processes need complex communication in hormonal and testicular to maintain male reproductive function.
Anak Agung Istri Dalem Cinthya Riris +2 more
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Effects of main compositions of Astragalus on estradiol synthesizing activing in TGF-β1-induced rat testicular Leydig cell line [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate the effects of the main compositions of Astragalus on testicular Leydig cells and their synthesis of estradiol(E2), P450arom under TGF-β1 induction.
LI Yan-rong, LIU Guang-wei, ZHAO Jing, LI Ya-jun
doaj
Environment International, 2022 In the past 50 years, testosterone (T) level in men has declined gradually. In this research, we discovered that acute exposure to 1-nitropyrene (1-NP), an environmental stressor from polluted atmosphere, reduced T contents by downregulating ...
Jian Li +11 more
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Quantitation of Leydig Cell in Testicular Biopsies of Gossypol Treated rats
The Iraqi Journal of Veterinary Medicine, 2005 Leydig cell density was evaluated quantitatively in bilateral testicular biopsies from twenty male rats of two equal groups Gossypol treated and control.
Muhannad A. A. Al Bayaty
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Ecotoxicology and Environmental Safety, 2021 Perfluorooctane sulfonate is related to male reproductive dysfunction in rats and humans. However, the underlying mechanism remains unknown. Here, we reported the effects of short-term exposure to perfluorooctane sulfonate on the regeneration of Leydig ...
Baiping Mao +7 more
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