Results 11 to 20 of about 23,359 (215)

INSL3 Expression in Leydig Cells is a Biomarker for Immunocastration in Boars: Transcriptional Evidence. [PDF]

Andrology
ABSTRACT Background Study aimed to obtain insights into physiological responses to immunocastration in pubertal boars by evaluating effects of alternative vaccination protocols and identifying a reliable immunocastration biomarker. Objectives It was hypothesized that the timing of gonadotropin‐releasing hormone (GnRH) suppression by immunocastration ...
Lukač NB, Škrlep M, Poklukar K, Ferjan P, Stefanski V, Fazarinc G, Vrecl M.   +6 more
europepmc   +2 more sources

Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro

BMC Pharmacology and Toxicology, 2019
Background It is an established fact that excess of glucocorticoids could cause the harmful effects, such as suppression on the male reproduction. Although glucocorticoids pharmacologically inhibit the Leydig cell function, their roles in Leydig cell ...
Jingwei Zhang, Guanghui Hu, Bisheng Huang, Dong Zhuo, Yujie Xu, Huitao Li, Xiangcheng Zhan, Ren-Shan Ge, Yunfei Xu   +8 more
doaj   +1 more source

Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway

Cells, 2022
There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the production of testosterone. Increasing evidence shows that melatonin benefits the reproductive process. This study mainly explores the protective effect and possible
Junqiang Zhang, Yuan Fang, Dongdong Tang, Xingyu Xu, Xiaoqian Zhu, Shusheng Wu, Hui Yu, Huiru Cheng, Ting Luo, Qunshan Shen, Yang Gao, Cong Ma, Yajing Liu, Zhaolian Wei, Xiaoyu Chen, Fangbiao Tao, Xiaojin He, Yunxia Cao   +17 more
doaj   +1 more source

Vitamin A Promotes Leydig Cell Differentiation via Alcohol Dehydrogenase 1

Frontiers in Endocrinology, 2018
Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin A in the regulation of testicular functions is clearly involved in rodents. It is essential for sperm production.
Yan Yang, Yan Yang, Jiao Luo, Dan Yu, Tiantian Zhang, Qilian Lin, Quan Li, Xupeng Wu, Zhijian Su, Qihao Zhang, Qi Xiang, Qi Xiang, Yadong Huang, Yadong Huang   +13 more
doaj   +1 more source

Testosterone secretion is affected by receptor tyrosine kinase c-Kit and anoctamin 1 activation in mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2022
Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
doaj   +1 more source

Long-term suppression of Leydig cell steroidogenesis prevents Leydig cell aging [PDF]

Proceedings of the National Academy of Sciences, 1999
Male aging is accompanied by reduced testosterone production by the Leydig cells, the testosterone-producing cells of the testis. The mechanism by which this occurs is unknown. Based on the observations that reactive oxygen is capable of damaging components of the steroidogenic pathway and that reactive oxygen is produced during steroidogenesis itself,
H, Chen, B R, Zirkin
openaire   +2 more sources

Plasma and testicular testosterone levels, volume density and number of Leydig cells and spermatogenic efficiency of rabbits

Brazilian Journal of Medical and Biological Research, 2002
Plasma and tissue testosterone concentrations were determined by radioimmunoassay in 12 eight-month-old sexually mature New Zealand White rabbits and evaluated for possible associations with spermatogenic efficiency as well as with volume density and ...
A.C.S. Castro, W.E. Berndtson, F.M. Cardoso   +2 more
doaj   +1 more source

Bone morphogenetic protein 4 inhibits rat stem/progenitor Leydig cell development and regeneration via SMAD-dependent and SMAD-independent signaling

Cell Death and Disease, 2022
Bone morphogenetic protein 4 (BMP4) is an important member of the transforming growth factor-β superfamily. BMP4 is expressed in the Leydig cell lineage. We hypothesized that BMP4 might regulate the development of stem/progenitor Leydig cells.
Xiaoheng Li, Yinghui Fang, Lanlan Chen, Hehua Quan, Yiyan Wang, Ren-Shan Ge   +5 more
doaj   +1 more source

Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells [PDF]

Development, 2018
ABSTRACT Previous studies have established that fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) show distinct functional characteristics. However, the lineage relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal ...
Yuichi Shima, Kanako Miyabayashi, Tetsuya Sato, Mikita Suyama, Yasuyuki Ohkawa, Masao Doi, Hitoshi Okamura, Kentaro Suzuki   +7 more
openaire   +2 more sources

The expression of aromatase, estrogen receptor a and estrogen receptor b in mouse Leydig cells in vitro that derived from cryptorchid males

European Journal of Histochemistry, 2009
A broad expression of aromatase and estrogen receptors (ERs) in the testis suggests an important role for estrogens in regulating testicular cell function and reproductive events.
M Kotula-Balak, M Gancarczyk, J Sadowska, B Bilinska   +3 more
doaj   +1 more source