Results 21 to 30 of about 23,359 (215)

FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis

International Journal of Endocrinology, 2021
Biosynthesis of testosterone occurs mainly in the testicular Leydig cells. Nur77, an orphan nuclear receptor that is expressed in response to the luteinizing hormone/cyclic adenosine monophosphate (LH/cAMP) signaling pathway, is one of the key factors ...
Hansle Kim, Sudeep Kumar, Keesook Lee
doaj   +1 more source

Fibroblast growth factor 9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells. [PDF]

PLoS ONE, 2014
Fibroblast growth factor 9 (FGF9) is a multifunctional polypeptide belonging to the FGF family and has functions related to bone formation, lens-fiber differentiation, nerve development, gap-junction formation and sex determination.
Meng-Shao Lai, Yu-Sheng Cheng, Pei-Rong Chen, Shaw-Jenq Tsai, Bu-Miin Huang   +4 more
doaj   +1 more source

Leydig Cells in Patients with Non-Obstructive Azoospermia: Do They Really Proliferate?

Life, 2021
Background: Non-obstructive azoospermia (NOA) is a form of male infertility caused by disorders of the testicular parenchyma and impaired spermatogenesis.
Dinko Hauptman, Marta Himelreich Perić, Tihana Marić, Ana Katušić Bojanac, Nino Sinčić, Zoran Zimak, Željko Kaštelan, Davor Ježek   +7 more
doaj   +1 more source

EVALUATION OF RAT LEYDIG CELL CULTURE COLLECTED WITH NYCODENZ GRADIENT IN PRODUCING TESTOSTERONE IN VITRO

Jurnal Kedokteran Hewan, 2018
The aim of this study was to evaluate the ability of rat’s Leydig cells collected with Nycodenz gradient in producing testosterone in vitro. Leydig cells were collected using 5 column of Nycodenz gradient (4, 8, 10, 12, and 15%) and cells were evaluated ...
Ekayanti Mulyawati Kaiin, Wahono Esthi Prasetyaningtyas   +1 more
doaj   +1 more source

Triadimefon increases fetal Leydig cell proliferation but inhibits its differentiation of male fetuses after gestational exposure

Ecotoxicology and Environmental Safety, 2021
Triadimefon is a broad-spectrum fungicide widely applied in the agriculture. It is believed to be an endocrine disruptor. Whether triadimefon can inhibit the development of fetal Leydig cells and the underlying mechanisms are unknown.
Liben Lin, Qiang Xu, Quanxu Chen, Haiqiong Chen, Yingfen Ying, Zengqiang Li, Song Zhang, Feifei Ma, Yige Yu, Ren-Shan Ge   +9 more
doaj   +1 more source

Silencing of MEG3 attenuated the role of lipopolysaccharides by modulating the miR-93-5p/PTEN pathway in Leydig cells

Reproductive Biology and Endocrinology, 2021
Background Leydig cells reflect the activation of inflammation, decrease of androgen production, inhibition of cell growth and promotion of cell apoptosis under orchitis. Maternally expressed gene 3 (MEG3) exerts a crucial role in various human diseases,
Xu Zhou, Jingliang He, Jinbo Chen, Yu Cui, Zhenyu Ou, Xiongbing Zu, Nenghui Liu   +6 more
doaj   +1 more source

Jagged1 intracellular domain modulates steroidogenesis in testicular Leydig cells.

PLoS ONE, 2020
Leydig cells represent the steroidogenic lineage of mammalian testis, which produces testosterone. Genetic evidence indicates the requirement of Notch signaling in maintaining a balance between differentiated Leydig cells and their progenitors during ...
Sudeep Kumar, Hee-Sae Park, Keesook Lee
doaj   +1 more source

Numeric and volumetric changes in Leydig cells during aging of rats [PDF]

Acta Cirúrgica Brasileira, 2017
Purpose: To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number.
Bruno Vinicius Duarte Neves, Fernando Lorenzini, Djanira Veronez, Eduardo Pereira de Miranda, Gabriela Duarte Neves, Rogério de Fraga   +5 more
doaj   +1 more source

Characterization of stem cells associated with seminiferous tubule of adult rat testis for their potential to form Leydig cells

Stem Cell Research, 2019
Adult testicular Leydig cells arise from stem cells in the neonatal and adult testis. The nature of these stem Leydig cells (SLCs) have not been well characterized.
Xiaoju Guan, Panpan Chen, Xingxing Zhao, Xinrui Hao, Fenfen Chen, Minpeng Ji, Xin Wen, Han Lin, Leping Ye, Haolin Chen   +9 more
doaj   +1 more source

Enniatin B1 induces damage to Leydig cells via inhibition of the Nrf2/HO-1 and JAK/STAT3 signaling pathways

Ecotoxicology and Environmental Safety
Enniatin B1 (ENN B1) is a mycotoxin that can be found in various foods. However, whether ENN B1 is hazardous to the reproductive system is still elusive.
Hongping Shen, Yili Cai, Keqi Zhu, Dong Wang, Rui Yu, Xueqin Chen   +5 more
doaj   +1 more source