Results 41 to 50 of about 23,359 (215)

Assessment of Gold‐Mediated Male Reproductive Dysfunction in Male WISTAR Rats Through Sperm Analysis and Testosterone Measurement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Gold has been used for centuries in both ornamental and medicinal contexts. More recently, gold compounds, containing ions or nanoparticles, have attracted attention for their anti‐inflammatory, anticancer, and diagnostic applications. Therefore, concerns about systemic toxicity and biodistribution have prompted investigations into the ...
Samira Maghraoui, Adrian Florea, Leila Tekaya   +2 more
wiley   +1 more source

A Short-Term Exposure to Tributyltin Blocks Leydig Cell Regeneration in the Adult Rat Testis

Frontiers in Pharmacology, 2017
Background: Tributyltin (TBT) is widely used as an antifouling agent that may cause reproductive toxicity. The mechanism of TBT on Leydig cell development is still unknown. The objective of the present study was to investigate whether a brief exposure to
Xiaolong Wu, Jianpeng Liu, Yue Duan, Shiyu Gao, Yao Lü, Xiaoheng Li, Qiqi Zhu, Xianwu Chen, Jing Lin, Leping Ye, Ren-Shan Ge, Ren-Shan Ge   +11 more
doaj   +1 more source

TRPV1 activation induces cell death of TM3 mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2021
The role of transient receptor potential vanilloid receptor-1 (TRPV1) has been primarily investigated in pain sensory neurons. Relatively, little research has been performed in testicular cells.
Eun-Jin Kim, Long Cao Dang, Marie Merci Nyiramana, Adrian S. Siregar, Min-Seok Woo, Chang-Woon Kim, Dawon Kang   +6 more
doaj   +1 more source

Molecular Investigations on Angiogenesis and Oxidative Stress in Roe Deer (Capreolus capreolus) Bucks' Testes Throughout the Reproductive Cycle

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Animals with seasonal reproductive cycles, as the Roe deer (Capreolus capreolus), have developed mechanisms to synchronize reproduction with the environmental cycle in order to optimize reproductive success through melatonin. Angiogenesis and oxidative stress are key processes in spermatogenesis, contributing to testicular remodeling and ...
Ilaria Troisio, Domenico Ventrella, Bálint Lóránt Hausz, Mattia Cesauri, Niccolò Ian Vannetti, Maria Laura Bacci, Alberto Elmi, Augusta Zannoni   +7 more
wiley   +1 more source

Transforming growth factor-β1 signaling represses testicular steroidogenesis through cross-talk with orphan nuclear receptor Nur77. [PDF]

PLoS ONE, 2014
Transforming growth factor- β1 (TGF-β1) has been reported to inhibit luteinizing hormone (LH) mediated-steroidogenesis in testicular Leydig cells. However, the mechanism by which TGF-β1 controls the steroidogenesis in Leydig cells is not well understood.
Eunsook Park, Chin-Hee Song, Jae-Il Park, Ryun-Sup Ahn, Hueng-Sik Choi, CheMyong Ko, Keesook Lee   +6 more
doaj   +1 more source

Therapeutic Potential of Fecal Microbiota Transplantation for Male Sexual Dysfunction: Evidence and Clinical Perspectives

Microbiota Medicine Research, EarlyView.
ABSTRACT Fecal microbiota transplantation (FMT), a microbiome‐based therapy, shows potential in treating male sexual dysfunction. Research into the influence of FMT on male sexual function has recently garnered increasing attention. This review aims to explore the impact of FMT on male sexual function and the underlying mechanisms, and to analyze the ...
Junyi Chen, Chenfeng Bu, Xia Li, Lei Wu, Xingxiang He   +4 more
wiley   +1 more source

The Fate of Leydig Cells in Men with Spermatogenic Failure

Life, 2022
The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment, play a vital role in male reproductive tract development, maintenance of proper spermatogenesis, and overall male reproductive function.
Daria Adamczewska, Jolanta Słowikowska-Hilczer, Renata Walczak-Jędrzejowska   +2 more
doaj   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

TGF-β1 regulation of estrogen production in mature rat Leydig cells. [PDF]

PLoS ONE, 2013
BACKGROUND: Besides androgens, estrogens produced in Leydig cells are also crucial for mammalian germ cell differentiation. Transforming growth factor-β1 (TGF-β1) is now known to have multiple effects on regulation of Leydig cell function.
Man-Li Liu, Huan Wang, Zong-Ren Wang, Yu-Fen Zhang, Yan-Qiu Chen, Fang-Hong Zhu, Yuan-Qiang Zhang, Jing Ma, Zhen Li   +8 more
doaj   +1 more source

Quantification of steroid hormones in free‐ranging Apennine wolf Canis lupus italicus hair samples collected post‐mortem

Wildlife Biology, EarlyView.
After decades of dramatic reductions in their populations, Italian wolves have begun recolonizing parts of their historic range. This growth in populations can lead to potential conflicts with human activities, which remain the main cause of wolf mortality.
Ilaria Troisio, Carmela Musto, Nicola Acquisti Casi, Nadia Govoni, Giuseppe Merialdi, Domenico Ventrella, Alberto Elmi, Mauro Delogu, Maria Laura Bacci   +8 more
wiley   +1 more source