Results 41 to 50 of about 1,469,506 (316)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

A comparison of house prices brought by English auctions and private negotiations in Melbourne [PDF]

, 1993
A comparison of house prices brought by English auctions and private negotiations produced evidence that the pricing mechanism matters, with the price maximizing choice a function of the level of market interest.Australian Policy Online (APO)'s Linked ...
Lusht, Kenneth M.
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Bibliographic standards and Linked Data. Towards a collaboration between cultural and commercial sectors

JLIS.it, 2013
The Central Institute for the Union Catalogue of Italian Libraries and Bibliographic Information (ICCU) is the National Bibliographic Agency for the coordination and dissemination of international standards and cataloguing rules within Italian libraries.
Patrizia Martini
doaj   +1 more source

Understanding patterns of library use among undergraduate students from different disciplines [PDF]

, 2014
Objective The objective of this study was to test whether routinely-generated library usage data could be linked with information about students to understand patterns of library use among students from different disciplines at the University of ...
Collins, Ellen, Stone, Graham
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

4. Using Linked Library Data in Working Research Notes [PDF]

, 2015
We describe how we are experimenting with using linked library data to connect the organizational infrastructures of libraries, archives, and special collections with those of researchers who use them. The site of this experimentation is Editors’ Notes, an open-source hosted service for organizing the library and archives-based research of documentary ...
Shaw, R, Golden, P, Buckland, M
openaire   +3 more sources

Studying Conceptual Models for Publishing Library Data to the Semantic Web [PDF]

, 2017
This thesis studies the library data and the way that linked data technologies may affect libraries. The thesis aims to contribute to the research regarding the devel-opment and implementation of a framework for the integration of bibliographic data in ...
R Smiraglia, S Strodl, S Zapounidou, S Zapounidou, S Zapounidou, V Ogle   +5 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Metadata framework and application profiles in the global structure of catalogs and digitization projects of the Vatican Library

JLIS.it, 2013
This paper will focus on the application profiles recently implemented in the new Vatican Library's discovery tool that interacts with interoperability standards and manages different metadata.
Paola Manoni
doaj   +1 more source