Results 71 to 80 of about 1,443,071 (277)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Linking Library Metadata to the Web: the German Experiences
JLIS.it, 2013 One of the major challenges of libraries today is to make metadata available for the usage and re-usage by researchers and the scientific community. Therefore it is necessary to open the cataloguing systems for non-restricted and completely free access.
Gabriele Meßmer
doaj +6 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Diffusion and adoption of Linked Data among libraries
Proceedings of the Association for Information Science and Technology, 2020 AbstractThrough content analyses of literature about the Linked Data (LD) adoption of individual libraries, this study found that the diffusion of LD among libraries is a decentralized process with high‐degree of reinvention and a continuous process that includes multiple stages and might last for many years.
openaire +2 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Implications of BIBFRAME and Linked Data for Libraries and Publishers
"Roll With the Times, or the Times Roll Over You", 2017 This article considers the current situation of transition from the machine-readable cataloging (MARC) formats to the Bibliographic Framework Initiative (BIBFRAME) data model, and the further step to organize and publish catalog information in the emerging linked data technology.
openaire +4 more sources
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Introduction to the Seminar Global interoperability and linked data in libraries
JLIS.it, 2013 Why a Linked data Seminar? Linked data provides a new language in the world of global communication: from the public administration, banks, insurance companies, to archives, libraries and museums. Global communication via Linked Data is about using the Web to connect related data that wasn't previously linked, or using the Web to lower the barriers to ...
openaire +8 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source