Results 61 to 70 of about 57,098 (267)

Bisphenol S Induces Lipid Metabolism Disorders in HepG2 and SK-Hep-1 Cells via Oxidative Stress

Toxics
Bisphenol S (BPS) is a typical endocrine disruptor associated with obesity. To observe BPS effects on lipid metabolism in HepG2 and SK-Hep-1 human HCC cells, a CCK-8 assay was used to assess cell proliferation in response to BPS, and the optimal ...
Kai-Xing Lin, Zi-Yao Wu, Mei-Lin Qin, Huai-Cai Zeng   +3 more
doaj   +1 more source

Lifecycles of EBV and Cancer

Uirusu, 2014
Epstein-Barr virus (EBV) is a member of gamma-herpesvirus, which can cause various types of tumor. Coexisting with the host for a long period of time, it has evolved unique and sophisticated strategy for survival by taking complicated, tactical modes of infection.
openaire   +3 more sources

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Stochastic Insights into Leakage Dynamics across Diverse Pipe Materials in Water Distribution Systems

Engineering Proceedings
This study developed more realistic stochastic models of pipe failures that incorporate leak types and dimensions based on different pipe materials. The distributions of pipe failure types and properties were identified by analysing photographic records ...
Soheila Beygi, Jakobus E. van Zyl, Brendon Harkness   +2 more
doaj   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Servicization of Product Lifecycle Management: Towards Service Lifecycle Management [PDF]

, 2016
Nowadays, many manufacturing industries are operating a process of servicization, id est the build-up of services to a product-centered offer. The implementation of service engineering into product-related activities requires a company to adapt to the new stakes on several levels, including strategic approaches and information systems.
Fabien Mahut, Matthieu Bricogne, Joanna Daaboul, Benoît Eynard   +3 more
openaire   +1 more source

A Sustainable Bio‐Based Epoxy Thermoset as a High‐Performance Alternative to BPA‐Based Resins

Advanced Science, EarlyView.
A rigid–flexible bio‐based epoxy network integrates soybean oil, lignin, and maleic anhydride to overcome the strength–toughness–sustainability trade‐off of conventional BPA epoxy. The thermoset delivers excellent performance as both a structural adhesive and a matrix for glass‐fabric composites, while enabling pH‐responsive degradation, environmental ...
Jiyun Qi, Xinyi Hui, Xipeng Zhang, Jia‐Long Wen, Tong‐Qi Yuan   +4 more
wiley   +1 more source

Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus

Scientific Reports
The aetiological mechanism of gestational diabetes mellitus (GDM) has still not been fully understood. The aim of this study was to explore the associations between functional genetic variants screened from a genome-wide association study (GWAS) and GDM ...
Gongchen Huang, Yan Sun, Ruiqi Li, Lei Mo, Qiulian Liang, Xiangyuan Yu   +5 more
doaj   +1 more source

Associations between the METS-IR index and cognitive function in community-dwelling Chinese middle-aged and older adult individuals: a cross-sectional study

Frontiers in Public Health
ObjectiveThe relationship between insulin resistance and cognitive function has long been a subject of interest, but the association between the metabolic syndrome-insulin resistance (METS-IR) index and cognitive impairment remains unclear.MethodsWe ...
Nian Jiang, Nian Jiang, Chenlu Ma, Chenlu Ma, Zhenning Feng, Zhenning Feng, Yongjun Tang, Yongjun Tang, Xiaolong Chen, Xiaolong Chen, Yingxu He, Yingxu He, Weiyi Pang, Weiyi Pang, Weiyi Pang   +14 more
doaj   +1 more source

Wake‐Up and Fatigue under Electrical Cycling in HfO2‐Based Ferroelectrics: Mechanisms and Strategies toward Reliable Devices

Advanced Science, EarlyView.
HfO2‐based ferroelectrics exhibit wake‐up and fatigue behaviors during electrical cycling, significantly affecting device endurance and reliability. These phenomena are governed by defect dynamics, including oxygen vacancy redistribution and charge trapping.
Hongseok Kim, Shinhyeong Lee, Hyojun Choi, Minseung Park, Hyunah Cho, Min Hyuk Park, Yunseok Kim   +6 more
wiley   +1 more source