Results 71 to 80 of about 56,030 (266)

Servicization of Product Lifecycle Management: Towards Service Lifecycle Management [PDF]

, 2016
Nowadays, many manufacturing industries are operating a process of servicization, id est the build-up of services to a product-centered offer. The implementation of service engineering into product-related activities requires a company to adapt to the new stakes on several levels, including strategic approaches and information systems.
Fabien Mahut, Matthieu Bricogne, Joanna Daaboul, Benoît Eynard   +3 more
openaire   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Stochastic Insights into Leakage Dynamics across Diverse Pipe Materials in Water Distribution Systems

Engineering Proceedings
This study developed more realistic stochastic models of pipe failures that incorporate leak types and dimensions based on different pipe materials. The distributions of pipe failure types and properties were identified by analysing photographic records ...
Soheila Beygi, Jakobus E. van Zyl, Brendon Harkness   +2 more
doaj   +1 more source

Lifecycles of EBV and Cancer

Uirusu, 2014
Epstein-Barr virus (EBV) is a member of gamma-herpesvirus, which can cause various types of tumor. Coexisting with the host for a long period of time, it has evolved unique and sophisticated strategy for survival by taking complicated, tactical modes of infection.
openaire   +3 more sources

Machine Learning‐Driven Prediction of Microplastic Aging Processes and Environmental Risk Assessment Across Multi‐Media Systems

Advanced Science, EarlyView.
This perspective proposes a cohesive machine learning strategy to decode microplastic aging. It advocates for Federated Learning to dismantle global data silos and introduces the TRACE framework (TRansport, Aging, Corona, Ecotoxicity). By integrating physics‐informed modeling with causal discovery, this approach bridges the laboratory‐field gap to ...
Yaping Lyu, Xinran Qiu, Xing Li, Tianhuan Yang, Xuetao Guo, Hao Qiu, Peng Zhang   +6 more
wiley   +1 more source

Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design

Advanced Science, EarlyView.
A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram, Mohit Chakraborty, Sai Mani Kumar Devathi, B. Pabitramohan Prusty, Rohit Batra   +4 more
wiley   +1 more source

Associations between the METS-IR index and cognitive function in community-dwelling Chinese middle-aged and older adult individuals: a cross-sectional study

Frontiers in Public Health
ObjectiveThe relationship between insulin resistance and cognitive function has long been a subject of interest, but the association between the metabolic syndrome-insulin resistance (METS-IR) index and cognitive impairment remains unclear.MethodsWe ...
Nian Jiang, Nian Jiang, Chenlu Ma, Chenlu Ma, Zhenning Feng, Zhenning Feng, Yongjun Tang, Yongjun Tang, Xiaolong Chen, Xiaolong Chen, Yingxu He, Yingxu He, Weiyi Pang, Weiyi Pang, Weiyi Pang   +14 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus

Scientific Reports
The aetiological mechanism of gestational diabetes mellitus (GDM) has still not been fully understood. The aim of this study was to explore the associations between functional genetic variants screened from a genome-wide association study (GWAS) and GDM ...
Gongchen Huang, Yan Sun, Ruiqi Li, Lei Mo, Qiulian Liang, Xiangyuan Yu   +5 more
doaj   +1 more source

Perinatal BPS exposure induces offspring neurotoxicity via ferroptosis mediated by the SLC7A11/GPX4 pathway

Ecotoxicology and Environmental Safety
Bisphenol S (BPS), a common substitute for bisphenol A, has raised considerable concern due to its potential neurotoxicity. However, the understanding of generational effect of BPS on neurotoxic effect is still unclear. Herein, parental pregnant mice and
Xinxin Guo, Meilin Qin, Kaixing Lin, Mengfen Pan, Nuo Xu, Yan Su, Zhensong Ma, Haozhe Zhou, Huaicai Zeng   +8 more
doaj   +1 more source