Results 91 to 100 of about 14,125,984 (386)

Measuring vertebrate telomeres: applications and limitations [PDF]

, 2004
Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic chromosomes that function in stabilizing chromosomal end integrity.
Allsopp RC, Barja G, Benetos A, Broccoli D, Chang E, Charnov E, Friedrich U, Gemmell NJ, Girondot M, Grant JD, Harley CB, IUCN, Jeanclos E, Kern S, Lambertsen RH, Meyne J, Miyashita N, Ogburn CE, Olsen E, Prowse KR, Rose MR, Slagboom PE, Stearns SC, Stearns SC, Turker M, Vaziri H, Watson J, Zeichner SL   +27 more
core   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Use of Carboxyhemoglobin as an Early Sign of Oxygenator Dysfunction in Patients Supported by Extracorporeal Membrane Oxygenation

Frontiers in Medicine, 2022
IntroductionPlasma free hemoglobin is the gold standard for monitoring hemolysis in extracorporeal membrane oxygenation (ECMO) but its routine use has some limitations. Carboxyhemoglobin (HbCO) is also a marker of intravascular hemolysis.
Vladimir L. Cousin, Vladimir L. Cousin, Raphaël Giraud, Raphaël Giraud, Benjamin Assouline, Benjamin Assouline, Ivo Neto Silva, Ivo Neto Silva, Karim Bendjelid, Karim Bendjelid   +9 more
doaj   +1 more source

Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan [PDF]

, 2010
The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (
Gispert, Suzana, Mack, Sandra J., Osiewacz, Heinz D., Ricciardi, Filomena, Scheckhuber, Christian Q., Strobel, Ingmar   +5 more
core   +2 more sources

Lifespan Trajectories of White Matter Changes in Rhesus Monkeys [PDF]

Cerebral Cortex, 2018
Progress in neurodevelopmental brain research has been achieved through the use of animal models. Such models not only help understanding biological changes that govern brain development, maturation and aging, but are also essential for identifying possible mechanisms of neurodevelopmental and age-related chronic disorders, and to evaluate possible ...
Carl-Fredrik Westin, Amanda E. Lyall, Amanda E. Lyall, Ryan Eckbo, Farzad Mortazavi, Martha E. Shenton, Martha E. Shenton, Sarina Karmacharya, Marek Kubicki, Marek Kubicki, Nikos Makris, Nikos Makris, Sylvain Bouix, Yogesh Rathi, George Papadimitriou, Ronald J. Killiany, Yingying Tang, Douglas L. Rosene, Madhura Baxi, Madhura Baxi, Ofer Pasternak, Natalia Chunga   +21 more
openaire   +2 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

A link between phenotypic robustness and life expectancy in Drosophila melanogaster

Вавиловский журнал генетики и селекции, 2017
Long-lived systems are expected to be stable, i. e. resistant to either external influences, or internal failures. Robustness of biological systems can be defined as a reciprocal value to their phenotypic plasticity expressed through a coefficient of ...
L. P. Zakharenko, D. V. Petrovskii, I. G. Dranov, S. A. Fedorova, N. S. Yudin, A. V. Pindyurin, Y. M.  Moshkin   +6 more
doaj   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Interleaved Pro/Anti-saccade Behavior Across the Lifespan

Frontiers in Aging Neuroscience, 2022
The capacity for inhibitory control is an important cognitive process that undergoes dynamic changes over the course of the lifespan. Robust characterization of this trajectory, considering age continuously and using flexible modeling techniques, is ...
Rachel Yep, Matthew L. Smorenburg, Heidi C. Riek, Olivia G. Calancie, Ryan H. Kirkpatrick, Ryan H. Kirkpatrick, Julia E. Perkins, Jeff Huang, Brian C. Coe, Donald C. Brien, Douglas P. Munoz, Douglas P. Munoz, Douglas P. Munoz   +12 more
doaj   +1 more source

Intercellular competitive growth dynamics with microenvironmental feedback [PDF]

arXiv, 2023
Normal life activities between cells rely crucially on the homeostasis of the cellular microenvironment, but aging and cancer will upset this balance. In this paper, we introduce the microenvironmental feedback mechanism to the growth dynamics of multicellular organisms, which changes the cellular competitive ability, and thereby regulates the growth ...
arxiv