Results 1 to 10 of about 1,524,347 (353)
Cells, 2021 A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan contexts, as their outermost sugar moiety. Among their functions, glycans engage complementary glycan binding proteins (lectins) to regulate cell physiology.
Anabel Gonzalez-Gil, Ronald L. Schnaar
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Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis
Pharmaceuticals, 2022 Immune checkpoint inhibitor (ICI) therapy has emerged as a major treatment option for a variety of cancers. Among the immune checkpoints addressed, the programmed death receptor 1 (PD-1) and its ligand PD-L1 are the key targets for an ICI.
Fabian Krutzek +2 more
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Glycols in the Synthesis of Zinc-Anilato Coordination Polymers
Crystals, 2022 We report the synthesis, structural investigation, and thermal behavior for three zinc-based 1D-coordination polymers with 3,6-di-tert-butyl-2,5-dihydroxy-p-benzoquinone, which were synthesized in the presence of different glycols.
Olesya Y. Trofimova +5 more
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Charge Transfer Chromophores Derived from 3d-Row Transition Metal Complexes
Molecules, 2022 A series of new charge transfer (CT) chromophores of “α-diimine-MII-catecholate” type (where M is 3d-row transition metals—Cu, Ni, Co) were derived from 4,4′-di-tert-butyl-2,2′-bipyridyl and 3,6-di-tert-butyl-o-benzoquinone (3,6-DTBQ) in accordance with ...
Kira I. Pashanova +7 more
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Molecules, 2021 Two heteroleptic NiII complexes combined the redox-active catecholate and 2,2′- bipyridine ligand platforms were synthesized to observe a photoinduced intramolecular ligand-to-ligand charge transfer (LL’CT, HOMOcatecholate → LUMOα-diimine).
Kira I. Pashanova +4 more
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Inhibitory Immune Checkpoint Receptors and Ligands as Prognostic Biomarkers in COVID-19 Patients
Frontiers in Immunology, 2022 Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2. During T-cell activation, the immune system uses different checkpoint pathways to maintain co-inhibitory and co-stimulatory signals.
Mohammad A. Al-Mterin +3 more
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Drug Delivery, 2022 The systemic drug has historically been preferred for the treatment of the majority of pathological conditions, particularly liver cancer. Indeed, this mode of treatment is associated with adverse reactions, toxicity, off-target accumulation, and rapid ...
Jianyong Ma +6 more
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Frontiers in Endocrinology, 2023 IntroductionNR5A1 and NR5A2 belong to an orphan nuclear receptor group, and approximately 60% of their amino acid sequences are conserved. Transcriptional regulation of NR5A receptors depends on interactions with co-factors or unidentified ligands ...
Maki Gau +9 more
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Frontiers in Bioengineering and Biotechnology, 2023 Small interfering RNA (siRNA)-mediated mRNA degradation approach have imparted its eminence against several difficult-to-treat genetic disorders and other allied diseases.
Rushikesh Fopase +6 more
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Estimating tissue-specific peptide abundance from public RNA-Seq data
Frontiers in Genetics, 2023 Several novel MHC class I epitope prediction tools additionally incorporate the abundance levels of the peptides’ source antigens and have shown improved performance for predicting immunogenicity.
Angela Frentzen +5 more
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