Metal Chalcogenide Clusters with Closed Electronic Shells and the Electronic Properties of Alkalis and Halogens [PDF]
, 2017 Clusters with filled electronic shells and a large gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) are generally energetically and chemically stable. Enabling clusters to become electron donors
Chauhan, Vikas +2 more
core +3 more sources
Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
Frontiers in Immunology, 2019 Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands.
Thayer K Darling, T. Lamb
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Proceedings, 2020 The plastic and metal pollution accumulating in the marine environment has given many researchers motivation to investigate and provide solutions to this problem. [...]
Thandiwe Crystal Totito +5 more
doaj +1 more source
Bis[μ-bis(diphenylphosphino)methane-К²P:P’]bis[(saccharinato-КN)- palladium(I)] dichloromethane solvate [PDF]
, 2002 The dimeric palladium(I) saccharinate complex [Pd₂(sac)₂(dppm)₂], has been characterized as its di¬chloro¬methane solvate, i.e. [Pd₂(C₇H₄NO₃S)₂(C₂₅H₂₂P₂)₂]•CH₂Cl₂.
Chung, Dong C. +2 more
core +2 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
FlexVDW: A machine learning approach to account for protein flexibility in ligand docking [PDF]
arXiv, 2023 Most widely used ligand docking methods assume a rigid protein structure. This leads to problems when the structure of the target protein deforms upon ligand binding. In particular, the ligand's true binding pose is often scored very unfavorably due to apparent clashes between ligand and protein atoms, which lead to extremely high values of the ...
arxiv
Dewetting-controlled binding of ligands to hydrophobic pockets [PDF]
Setny et al., PRL 103, 187801 (2009), 2009 We report on a combined atomistic molecular dynamics simulation and implicit solvent analysis of a generic hydrophobic pocket-ligand (host-guest) system. The approaching ligand induces complex wetting/dewetting transitions in the weakly solvated pocket.
arxiv +1 more source
Dissecting the Bond Formation Process of $d^{10}$-Metal-Ethene Complexes with Multireference Approaches [PDF]
, 2015 The bonding mechanism of ethene to a nickel or palladium center is studied by the density matrix renormalization group algorithm, the complete active space self consistent field method, coupled cluster theory, and density functional theory. Specifically,
Ayers, Paul W. +6 more
core +2 more sources
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal
Nature, 2017 The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear ...
Kelley S. Yan +32 more
semanticscholar +1 more source