Results 101 to 110 of about 2,433,325 (381)

Accurate Prediction of Drug Activity by Computational Methods: Importance of Thermal Capacity

Molecules
Heat capacity is one of the most important thermodynamic quantities in protein biochemistry. Upon the binding of small molecules, a change in the heat capacity of proteins is generally observed, and this is often used in drug discovery.
Luigi Leonardo Palese
doaj   +1 more source

Human Cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against NK cell cytotoxicity. [PDF]

, 2003
The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC) class I-related ligands, including the MIC and ULBP proteins.
Chalupny, NJ, Cosman, D, Dosch, S, Dunn, C, Johnson, DC, Sivakumar, PV, Sutherland, CL   +6 more
core  

Efficacy of Pembrolizumab Monotherapy for Advanced Gastric/Gastroesophageal Junction Cancer with Programmed Death Ligand 1 Combined Positive Score ≥10 [PDF]

, 2021
Zev A. Wainberg, Charles S. Fuchs, Josep Tabernero, Kohei Shitara, Kei Muro, Eric Van Cutsem, Yung‐Jue Bang, Hyun Cheol Chung, Kensei Yamaguchi, Eniko Varga, Jen‐Shi Chen, Daniel Hochhauser, Peter Thuss‐Patience, Salah‐Eddin Al‐Batran, Marcelo Garrido, Uma Kher, Chie-Schin Shih, Sukrut Shah, Pooja Bhagia, Joseph Chao   +19 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Diffusion and the physics of chemoreception [PDF]

, 1983
This review provides a manual which enables the reader to perform calculations on the rate with which a biological cell can capture certain chemical compounds (ligands) which are essential to its survival and which diffuse in its environment.
Wiegel, F.W.
core   +4 more sources

Surface Composition Dependent Ligand Effect in Tuning the Activity of Nickel–Copper Bimetallic Electrocatalysts toward Hydrogen Evolution in Alkaline [PDF]

, 2020
Chao Wei, Yuanmiao Sun, Günther G. Scherer, Adrian C. Fisher, Matthew Sherburne, Joel W. Ager, Zhichuan J. Xu   +6 more
openalex   +1 more source

NK cell receptor and ligand composition influences the clearance of SARS-CoV-2 [PDF]

, 2021
Wan-Chen Hsieh, En‐Yu Lai, Yuting Liu, Yi‐Fu Wang, Yi-Shiuan Tzeng, Lu Cui, Yun‐Ju Lai, Hsiang‐Chi Huang, Jia‐Hsin Huang, Hung-Chih Ni, Dong-Yan Tsai, Jian‐Jong Liang, Chun‐Che Liao, Ya-Ting Lu, Laurence Jiang, Ming‐Tsan Liu, Jann‐Tay Wang, Sui‐Yuan Chang, Chung‐Yu Chen, Hsing-Chen Tsai, Yao‐Ming Chang, Gerlinde Wernig, Chia-Wei Li, Kuo‐I Lin, Yi‐Ling Lin, Huai‐Kuang Tsai, Yen‐Tsung Huang, Shih‐Yu Chen   +27 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Role of PPARs in Disease

Cells, 2020
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand-activated transcription factors. They exist in three isoforms: PPARα, PPARβ/δ, and PPARγ.
Nicole Wagner, Kay-Dietrich Wagner
doaj   +1 more source

Synchronous and symmetric migration of Drosophila caudal visceral mesoderm cells requires dual input by two FGF ligands [PDF]

, 2012
Caudal visceral mesoderm (CVM) cells migrate synchronously towards the anterior of the Drosophila embryo as two distinct groups located on each side of the body, in order to specify longitudinal muscles that ensheath the gut.
Ghosh, Srimoyee, Kadam, Snehalata, Stathopoulos, Angelike   +2 more
core   +1 more source