Results 281 to 290 of about 2,433,325 (381)

Predicting the binding residues of four small molecule ligands by utilizing ensemble algorithms with additional correlation features. [PDF]

Sci Rep
Gao S, Hu H, Hu X, Feng Z, Chen S, Yao Y, Tang B.   +6 more
europepmc   +1 more source

Self‐Reinforcing Degradation of Solution‐Processed Small‐Molecule OLEDs: Excited‐States and Molecular Interactions as Key Triggers

Advanced Functional Materials, EarlyView.
Self‐reinforcing degradation in solution‐processed small‐molecule organic light‐emitting diodes (OLEDs) arises from charge accumulation and exciton‐polaron interactions, leading to molecular aggregation and efficiency loss. This study uncovers the fundamental mechanisms behind this degradation and introduces strategic material engineering approaches ...
Eonji Cha, Junwon Jeon, Hyeon Woo Kim, Han Uk Lee, Joo Yoon Woo, Jun‐Su Yeo, Hyuk Bin Kwon, Sung Beom Cho, Tae‐Hee Han   +8 more
wiley   +1 more source

Graph neural networks for predicting metal-ligand coordination of transition metal complexes. [PDF]

Proc Natl Acad Sci U S A
Toney JW, St Michel RG, Garrison AG, Kevlishvili I, Kulik HJ.   +4 more
europepmc   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Molecular docking insights of Nigella sativa compounds as potential antiviral inhibitory agents against the replication-machinery proteins VPg and RdRP in rabbit hemorrhagic disease virus (RHDV). [PDF]

Virol J
Afifi YR, El-Akkad TA, Badr OA, Ibrahim SD, Serag AM.   +4 more
europepmc   +1 more source

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

Advanced Functional Materials, EarlyView.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang, Lasse Riediger, Qi Rao, Xun Xu, Yan Nie, Yiduo Zhou, Junyao Zhang, Peng Tang, Weiwei Wang, Frank Tacke, Adrien Guillot, Ludovic Vallier, Irene Talon, Wenzhong Li, Yi‐An Yang, Rainer Haag, Nan Ma   +16 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Computational Modelling of Imidazole Protection of Coordinated Gadolinium Tetraphenylporphyrine Against Molecular Oxygen Attack. [PDF]

Molecules
Pomogaev V, Lukyanov D, Solovyeva E.
europepmc   +1 more source