Results 31 to 40 of about 2,296,826 (424)
Aptamer-Based Technologies in Foodborne Pathogen Detection
Frontiers in Microbiology, 2016 Aptamers are single stranded DNA or RNA ligands, which can be selected by a method called systematic evolution of ligands by exponential enrichment (SELEX); and they can specifically recognize and bind to their targets.
Jun Teng +7 more
doaj +1 more source
Balancing specificity, sensitivity and speed of ligand discrimination by zero-order ultraspecificity [PDF]
Phys. Rev. E 96, 012405 (2017), 2016 Specific interactions between receptors and their target ligands in the presence of non-target ligands are crucial for biological processes such as T cell ligand discrimination. To discriminate between the target and non-target ligands, cells have to increase specificity by amplifying the small differences in affinity among ligands.
arxiv +1 more source
Frontiers in Molecular Neuroscience, 2018 C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease.
Svenja Kankowski +8 more
doaj +1 more source
Translocator protein in the rise and fall of central nervous system neurons
Frontiers in Cellular Neuroscience, 2023 Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane, has historically been associated with the transport of cholesterol in highly steroidogenic tissues though it is found in all cells throughout the mammalian body ...
Garett Cheung +2 more
doaj +1 more source
Physical limit to concentration sensing amid spurious ligands [PDF]
Phys. Rev. Lett. 115, 038102 (2015), 2015 To adapt their behaviour in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may bind nonspecifically to receptors, and when their concentration is large, this binding activity may interfere with the sensing of the ligand of interest.
arxiv +1 more source
The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs [PDF]
, 2013 G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential.
Hudson, Brian D. +2 more
core +1 more source
New insights in the immunobiology of IL 1 family members
Frontiers in Immunology, 2013 The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation, and plays an essential role in the non-specific innate response to infection.
Frank Van De Veerdonk, Mihai eNetea
doaj +1 more source
CAT-Site: Predicting Protein Binding Sites Using a Convolutional Neural Network
Pharmaceutics, 2022 Identifying binding sites on the protein surface is an important part of computer-assisted drug design processes. Reliable prediction of binding sites not only assists with docking algorithms, but it can also explain the possible side-effects of a ...
Žan Hafner Petrovski +2 more
doaj +1 more source
Ligand-Mediated Interactions between Nanoscale Surfaces Depend Sensitively and Nonlinearly on Temperature, Facet Dimensions, and Ligand Coverage [PDF]
ACS Nano, 2016, 10, pp 1877-1887, 2018 Nanoparticles are often covered in ligand monolayers, which can undergo a temperature-dependent order-disorder transition that switches the particle-particle interaction from repulsive to attractive in solution. In this work, we examine how changes in the ligand surface coverage and facet dimensions affect the ordering of ligands, the arrangement of ...
arxiv +1 more source
Stereoelectronic effects on the binding of neutral Lewis bases to CdSe nanocrystals [PDF]
, 2018 Using P-31 nuclear magnetic resonance (NMR) spectroscopy, we monitor the competition between tri-nbutylphosphine (Bu3P) and various amine and phosphine ligands for the surface of chloride terminated CdSe nanocrystals.
Anderson, Nicholas C +4 more
core +2 more sources