Results 31 to 40 of about 860,212 (198)
New insights in the immunobiology of IL 1 family members
Frontiers in Immunology, 2013 The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation, and plays an essential role in the non-specific innate response to infection.
Frank Van De Veerdonk, Mihai eNetea
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Antimicrobial Activity of Mononuclear and Bionuclear Nitrite Complexes of Platinum (II) and Platinum (IV) [PDF]
Техника и технология пищевых производств, 2020 Introduction. Pathogens keep evolving and develop resistance to antimicrobial drugs. As a result, science is constantly searching for new antimicrobial agents.
Salishcheva Olesya V. +2 more
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Role of PPAR Receptor and Ligands in the Pathogenesis and Therapy of Hematologic Malignancies
Hemato, 2022 The Peroxisome proliferator-activated receptors (PPARs) play vital roles in regulating cellular differentiation, proliferation, and caspase-mediated cell death pathways. They are regarded as promising targets for anti-tumor drug development, particularly
Jian Wu, Min Zhang, Allison Faircloth
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Metal–ligand cooperation at tethered π-ligands
Dalton Transactions, 2016 Recent advances in the use of tethered π-coordinating ligands for metal–ligand cooperation.
Dide G. A. Verhoeven, Marc-Etienne Moret
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The Nature of Ligand Efficiency [PDF]
Journal of Cheminformatics, 2018 Ligand efficiency is a widely used design parameter in drug discovery. It is calculated by scaling affinity by molecular size and has a nontrivial dependency on the concentration unit used to express affinity that stems from the inability of the logarithm function to take dimensioned arguments.
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Molecules, 2020 Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities. Opioids act through the opioid receptors, the family of G-protein coupled receptors (GPCRs) that mediate pain relief
Abdelfattah Faouzi +2 more
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Affibody-Binding Ligands [PDF]
International Journal of Molecular Sciences, 2020 While antibodies remain established therapeutic and diagnostic tools, other protein scaffolds are emerging as effective and safer alternatives. Affibodies in particular are a new class of small proteins marketed as bio-analytic reagents. They feature tailorable binding affinity, low immunogenicity, high tissue permeation, and high expression titer in ...
Annalisa Barozzi +4 more
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On the polarization of ligands by proteins [PDF]
Physical Chemistry Chemical Physics, 2020 The ligand polarization energy is evaluated for 286 crystallographic complexes from the PDBBind Core Set. It is found to be a substantial and variable highly fraction of the total protein–ligand interaction energy.
Soohaeng Yoo Willow +4 more
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Frontiers in Plant Science, 2018 Iron and Zn deficiencies are worldwide nutritional disorders that can be alleviated by increasing the metal concentration of rice (Oryza sativa L.) grains via bio-fortification approaches.
Pablo Díaz-Benito +9 more
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Frontiers in Marine Science, 2016 In recent years, electrospray-ionization mass spectrometry (ESI-MS) has been increasingly used to complement the bulk determination of metal-ligand equilibria, for example via competitive ligand exchange-adsorptive cathodic stripping voltammetry (CLE ...
Hannelore Waska +2 more
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