Results 51 to 60 of about 2,433,325 (381)

First-Row Transition Metal (De)Hydrogenation Catalysis Based On Functional Pincer Ligands.

Chemical Reviews, 2018
The use of 3d metals in de/hydrogenation catalysis has emerged as a competitive field with respect to "traditional" precious metal catalyzed transformations.
Lukas Alig, M. Fritz, S. Schneider
semanticscholar   +1 more source

New insights in the immunobiology of IL 1 family members

Frontiers in Immunology, 2013
The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation, and plays an essential role in the non-specific innate response to infection.
Frank Van De Veerdonk, Mihai eNetea
doaj   +1 more source

Facetted patchy particles through entropy-driven patterning of mixed ligand SAMS

, 2011
We present a microscopic theory that describes the ordering of two distinct ligands on the surface of a faceted nanoparticle. The theory predicts that when one type of ligand is significantly bulkier than all others, the larger ligands preferentially ...
Aaron Santos, Ahmadi, Alder, Brak, Browne, Cardy, Centrone, Clark, Daniel, Dimarzio, Doppelbauer, Duplantier, Frenkel, Glotzer, Grabiner, Guo, Haji-Akbari, Hammersley, Hill, Hong, Jackson, Jaime Andres Millan, Jian, Jiang, Klymko, Kuna, Lane, Li, Love, Maye, Miller, Millstone, Mirkin, Nykypanchuk, Pacholski, Parak, Paul, Pronk, Puntes, Quan, Santos, Schreiber, Sciortino, Sharon C. Glotzer, Singh, Singh, Singh, Sun, Sun, Tang, Tian, Tkachenko, Ulman, Van Rensburg, Wang, Wilber, Williamson, Wood, Zhang, Zhang, Zhao, Zhao, Ziherl   +62 more
core   +1 more source

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies [PDF]

, 2010
Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised.
Aime, Aime, Aime, Aime, Aime, Ali, Andrew J. P. White, Antoni, Beeta Balali-Mood, Behnam Azad, Bottrill, Bryson, Burdinski, Caravan, Cattaneo, Chapon, Cheng, Cilliers, De Leon-Rodriguez, De Leon-Rodriguez, Delgado, Faulkner, Fields, Gabriel, Guo, Hermann, Iten, Joachim H. G. Steinke, Jonathan Martinelli, Kaneshiro, Langereis, Major, Mani, Mark F. Lythgoe, Maumela, Montgomery, Moore, Muller, New, Oliver, Patrizia Ferretti, Pratesi, Rachael Panizzo, Ramon Vilar, Roosenburg, Schlesinger, Tan, Trokowski, Villaraza, Viola-Villegas, Viswanathan, Wu, Xu, Zhang, Zucchi   +54 more
core   +1 more source

A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors

Frontiers in Immunology
IntroductionNatural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and tumor cells. Their function relies on the dynamic balance between activating and inhibitory signals, which are mediated by receptors ...
Paolo Romania, Loredana Cifaldi, Loredana Cifaldi, Paula Gragera, Valerio D’Alicandro, Matteo Caforio, Valentina Folgiero, Valeria Lucarini, Ombretta Melaiu, Ombretta Melaiu, Roberto Bei, Franco Locatelli, Franco Locatelli, Doriana Fruci   +13 more
doaj   +1 more source

Role of PPAR Receptor and Ligands in the Pathogenesis and Therapy of Hematologic Malignancies

Hemato, 2022
The Peroxisome proliferator-activated receptors (PPARs) play vital roles in regulating cellular differentiation, proliferation, and caspase-mediated cell death pathways. They are regarded as promising targets for anti-tumor drug development, particularly
Jian Wu, Min Zhang, Allison Faircloth
doaj   +1 more source

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]

, 2004
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Auernhammer, Christoph J., Cengic, N., Dorn, F., Engelhardt, D., Isele, N. B., Kopp, F. B., Senaldi, G., Spottl, G., Vlotides, G., Weber, M. M.   +9 more
core   +1 more source

GPCRdb in 2018: adding GPCR structure models and ligands

Nucleic Acids Res., 2017
G protein-coupled receptors are the most abundant mediators of both human signalling processes and therapeutic effects. Herein, we report GPCRome-wide homology models of unprecedented quality, and roughly 150 000 GPCR ligands with data on biological ...
Gáspár Pándy-Szekeres, Christian Munk, Ts. Tsonkov, Stefan Mordalski, K. Harpsøe, A. Hauser, A. Bojarski, David E. Gloriam   +7 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Machine Learning Methods as a Cost-Effective Alternative to Physics-Based Binding Free Energy Calculations

Molecules
The rank ordering of ligands remains one of the most attractive challenges in drug discovery. While physics-based in silico binding affinity methods dominate the field, they still have problems, which largely revolve around forcefield accuracy and ...
Nupur Bansal, Ye Wang, Simone Sciabola
doaj   +1 more source