Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems
Cancers, 2019 Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on surface modification of NPs with biological ligands.
Jihye Yoo +4 more
semanticscholar +1 more source
Role of PPAR Receptor and Ligands in the Pathogenesis and Therapy of Hematologic Malignancies
Hemato, 2022 The Peroxisome proliferator-activated receptors (PPARs) play vital roles in regulating cellular differentiation, proliferation, and caspase-mediated cell death pathways. They are regarded as promising targets for anti-tumor drug development, particularly
Jian Wu, Min Zhang, Allison Faircloth
doaj +1 more source
Cannabinoid Ligands Targeting TRP Channels
Frontiers in Molecular Neuroscience, 2019 Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of chemical and physical stimuli.
Chanté Muller, P. Morales, P. Reggio
semanticscholar +1 more source
Antimicrobial Activity of Mononuclear and Bionuclear Nitrite Complexes of Platinum (II) and Platinum (IV) [PDF]
Техника и технология пищевых производств, 2020 Introduction. Pathogens keep evolving and develop resistance to antimicrobial drugs. As a result, science is constantly searching for new antimicrobial agents.
Salishcheva Olesya V. +2 more
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LigParGen web server: an automatic OPLS-AA parameter generator for organic ligands
Nucleic Acids Res., 2017 The accurate calculation of protein/nucleic acid–ligand interactions or condensed phase properties by force field-based methods require a precise description of the energetics of intermolecular interactions.
Leela S. Dodda +3 more
semanticscholar +1 more source
Advances on Mrgprs itch receptors and their ligands
Pifu-xingbing zhenliaoxue zazhi, 2023 Although histamine is an important physiologically active substance in pruritus,antihistamine drugs can only relieve a small proportion of symptoms in chronic pruritus.
Jing HU, Zhijian CAO
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Thermodynamically Optimized Machine-learned Reaction Coordinates for Hydrophobic Ligand Dissociation [PDF]
, 2023 Ligand unbinding is mediated by the free energy change, which has intertwined contributions from both energy and entropy. It is important but not easy to quantify their individual contributions. We model hydrophobic ligand unbinding for two systems, a methane particle and a C60 fullerene, both unbinding from hydrophobic pockets in all-atom water.
arxiv +1 more source
Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes
Molecules, 2016 The complex [Os(btzpy)2][PF6]2 (1, btzpy = 2,6-bis(1-phenyl-1,2,3-triazol-4-yl)pyridine) has been prepared and characterised. Complex 1 exhibits phosphorescence (λem = 595 nm, τ = 937 ns, φem = 9.3% in degassed acetonitrile) in contrast to its known ...
Salem A. E. Omar +5 more
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Aryl Hydrocarbon Receptor as an Anticancer Target: An Overview of Ten Years Odyssey
Molecules, 2023 Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor belonging to the basic helix–loop–helix (bHLH)/per-Arnt-sim (PAS) superfamily, is traditionally known to mediate xenobiotic metabolism.
Hamza Hanieh +4 more
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First-Row Transition Metal (De)Hydrogenation Catalysis Based On Functional Pincer Ligands.
Chemical Reviews, 2018 The use of 3d metals in de/hydrogenation catalysis has emerged as a competitive field with respect to "traditional" precious metal catalyzed transformations.
Lukas Alig, M. Fritz, S. Schneider
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