Results 61 to 70 of about 860,212 (198)

New efficient ligand for sub-mol % copper-catalyzed C–N cross-coupling reactions running under air

open access: yesBeilstein Journal of Organic Chemistry, 2012
A new efficient ligand, N,N’’-dimethyldiethylene triamine (DMDETA), has been synthesized and evaluated for sub-mol % copper-catalyzed C–N cross-coupling reactions. The efficiency of the ligand was determined by kinetic methods.
Per-Fredrik Larsson   +2 more
doaj   +1 more source

Machine Learning Methods as a Cost-Effective Alternative to Physics-Based Binding Free Energy Calculations

open access: yesMolecules
The rank ordering of ligands remains one of the most attractive challenges in drug discovery. While physics-based in silico binding affinity methods dominate the field, they still have problems, which largely revolve around forcefield accuracy and ...
Nupur Bansal, Ye Wang, Simone Sciabola
doaj   +1 more source

A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors

open access: yesFrontiers in Immunology
IntroductionNatural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and tumor cells. Their function relies on the dynamic balance between activating and inhibitory signals, which are mediated by receptors ...
Paolo Romania   +13 more
doaj   +1 more source

Expression of bone morphogenetic protein signaling pathway players in the jejunum and colon of adult rats

open access: yesEuropean Journal of Histochemistry
The bone morphogenetic protein (BMP) pathway, which plays a crucial role in the control of intestinal epithelial cell homeostasis, has been studied in mice and humans, leading to an understanding of its involvement in several intestinal pathologies ...
Emma Cogo   +6 more
doaj   +1 more source

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