Results 61 to 70 of about 1,747,583 (341)
A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors
Frontiers in ImmunologyIntroductionNatural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and tumor cells. Their function relies on the dynamic balance between activating and inhibitory signals, which are mediated by receptors ...
Paolo Romania +13 more
doaj +1 more source
Experimental study on VOCs adsorption by Zr-MOFs synthesized with different ligands
能源环境保护, 2023 Zirconium-based MOFs adsorbent materials with different ligands, including: UIO - 66, UIO-66-NH_2, UIO-66-NDC and UIO-67 were hydrothermally synthesized using terephthalic acid as the base ligand and functionalized functional group ligands 2 ...
JING Cha +6 more
doaj +1 more source
Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
Frontiers in Immunology, 2019 Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands.
Thayer K Darling, T. Lamb
semanticscholar +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Accurate Prediction of Drug Activity by Computational Methods: Importance of Thermal Capacity
MoleculesHeat capacity is one of the most important thermodynamic quantities in protein biochemistry. Upon the binding of small molecules, a change in the heat capacity of proteins is generally observed, and this is often used in drug discovery.
Luigi Leonardo Palese
doaj +1 more source
Proceedings, 2020 The plastic and metal pollution accumulating in the marine environment has given many researchers motivation to investigate and provide solutions to this problem. [...]
Thandiwe Crystal Totito +5 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal
Nature, 2017 The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear ...
Kelley S. Yan +32 more
semanticscholar +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source