Results 211 to 220 of about 125,351 (338)

Ubiquitination of Sec22b by a novel Legionella pneumophila ubiquitin E3 ligase

, 2023
Kelong Ma, Rundong Shu, Hongtao Liu, Jiaqi Fu, Zhao‐Qing Luo, Jiazhang Qiu   +5 more
openalex   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Hypoxia Increases Cardiac Proteasomal Activity and Differentially Modulates Cullin-RING E3 Ligases in the Naked Mole-Rat <i>Heterocephalus glaber</i>. [PDF]

Muscles
Ingelson-Filpula WA, Kadamani KL, Ojaghi M, Pamenter ME, Storey KB.   +4 more
europepmc   +1 more source

Ub-POD: A Ubiquitin-Specific Proximity-Dependent Labeling Technique to Identify E3 Ubiquitin Ligase Substrates in Human Cells

Urbi Mukhopadhyay, Sophie Levantovsky, Christian Behrends, Sagar Bhogaraju   +3 more
openalex   +1 more source

Termination of NF-κB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase [PDF]

, 2009
Lénia Rodrigues, Josina Filipe, Mark P. Seldon, Lídia Fonseca, Josef Anrather, Miguel P. Soares, J. Pedro Simas   +6 more
openalex   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Ubiquitin E3 Ligases and p53 in Doxorubicin-Induced Cardiotoxicity. [PDF]

Int J Mol Sci
Tachibana S, Otaki Y, Goto J, Watanabe T, Watanabe M.   +4 more
europepmc   +1 more source

Drosophila Roc1a Encodes a RING-H2 Protein with a Unique Function in Processing the Hh Signal Transducer Ci by the SCF E3 Ubiquitin Ligase

, 2021
Maher Noureddine, Timothy Donaldson, Stephen B. Thacker, Robert J. Duronio   +3 more
openalex   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Chimeric degraders in neurodegenerative diseases: Challenges and future directions. [PDF]

J Transl Int Med
Zheng H, Cui K, Mao J, Wan Y, Zheng J.
europepmc   +1 more source