Results 91 to 100 of about 36,737 (275)

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker   +2 more
wiley   +1 more source

First third-generation CAR T cell application targeting CD19 for the treatment of systemic IgM AL amyloidosis with underlying marginal zone lymphoma

open access: yesBiomarker Research, 2023
Light chain amyloidosis (AL) is a rare disease caused by the generalized deposition of misfolded free light chains. Patients with immunoglobulin M gammopathy (IgM) and indolent B-cell lymphoma such as marginal zone lymphoma (MZL) may in some instances ...
Felix Korell   +8 more
doaj   +1 more source

Prognostic Impact of the Hevylite Assay in Patients With IgG or IgA Multiple Myeloma Treated Within the GMMG‐MM5 Trial

open access: yesEuropean Journal of Haematology, Volume 116, Issue 3, Page 226-234, March 2026.
ABSTRACT Response assessment during treatment of multiple myeloma (MM) typically relies on immunofixation and serum electrophoresis. However, low levels of IgG and especially IgA paraprotein are difficult to quantify reliably. The Hevylite Assay quantifies the kappa and lambda fractions of IgG and IgA separately and is useful to determine response to ...
Tim Richardson   +125 more
wiley   +1 more source

Classic features of primary systemic amyloidosis (AL amyloidosis) leading to diagnosis of plasma cell myeloma [PDF]

open access: yes, 2019
The diagnosis of primary systemic amyloidosis, also known as AL (amyloid light-chain) amyloidosis, is often delayed owing to its nonspecific manifestations as well as its rarity.
Behrens, Emily   +3 more
core  

Enhanced Detection of Multiple Myeloma Cells by Next‐Generation Flow Cytometry Following Density Gradient Medium Separation

open access: yesEuropean Journal of Haematology, Volume 116, Issue 3, Page 256-266, March 2026.
ABSTRACT Introduction Following treatment, relapse of Multiple Myeloma (MM) occurs due to measurable residual disease (MRD). As therapeutic options expand, advances in response assessment become more critical, necessitating more sensitive MRD detection methods.
Aisling O'Brien   +2 more
wiley   +1 more source

Echocardiographic phenotype for refined risk stratification and treatment selection in light chain amyloidosis with heart failure [PDF]

open access: green, 2023
Hong Yang   +8 more
openalex   +1 more source

Historic characteristics and mortality of patients in the Swiss Amyloidosis Registry

open access: yesSwiss Medical Weekly
AIMS OF THE STUDY: Systemic amyloidoses are rare protein-folding diseases with heterogeneous, often nonspecific clinical presentations. To better understand systemic amyloidoses and to apply state-of-the-art diagnostic pathways and treatment, the ...
Sofie Brouwers   +17 more
doaj   +1 more source

Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Hereditary Transthyretin Amyloidosis Polyneuropathy

open access: yesJournal of the Peripheral Nervous System, Volume 31, Issue 1, March 2026.
ABSTRACT Background and Aims In individuals with hereditary transthyretin amyloidosis (ATTRv) polyneuropathy, monitoring of disease progression and treatment response is crucial. The objective is to determine if serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) are reliable biomarkers of ATTRv polyneuropathy ...
Valentin Loser   +9 more
wiley   +1 more source

Light chain type predicts organ involvement and survival in AL amyloidosis patients receiving stem cell transplantation

open access: yesBlood Advances, 2018
: We evaluated the impact of light chain type, lambda (λ) or kappa (κ), on disease features and outcomes in patients with immunoglobulin light chain (AL) amyloidosis receiving stem cell transplant at the Mayo Clinic between October 2002 and August 2016 ...
M Hasib Sidiqi   +14 more
doaj   +1 more source

Home - About - Disclaimer - Privacy