Results 201 to 210 of about 73,744 (247)

Axially swept open-top light-sheet microscopy for densely labeled clinical specimens. [PDF]

Opt Lett
Bishop KW, Erion Barner LA, Baraznenok E, Lan L, Poudel C, Brenes D, Serafin RB, True LD, Vaughan JC, Glaser AK, Liu JTC.   +10 more
europepmc   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy. [PDF]

Nat Methods
Attarpour A, Osmann J, Rinaldi A, Qi T, Lal N, Patel S, Rozak M, Yu F, Cho N, Squair J, McLaurin J, Raffiee M, Deisseroth K, Courtine G, Ye L, Stefanovic B, Goubran M.   +16 more
europepmc   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Compact scattering-based light sheet microscopy probe using a custom miniature objective lens. [PDF]

J Opt Microsyst
Zhao J, Kim Y, Sugimura M, Marcelino K, Romero R, Liang B, Khan M, Yang E, Kang D.   +8 more
europepmc   +1 more source

Orthogonal Ionic Liquid‐Based Extraction Strategy Enables Amyloid‐Specific Profiling of Aggregate Proteome

Advanced Science, EarlyView.
An orthogonal ionic‐liquid extraction (Orth‐iEA) enables selective isolation of amyloid fibrils. TMGBF4 disrupts hydrogen‐bonded β‐sheet networks to solubilize amyloid aggregates, whereas C12ImCl interacts with hydrophobic regions of non‐amyloid proteins.
Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao, Lihua Zhang   +10 more
wiley   +1 more source

pathoDISCO-HE: Towards light sheet microscopy enabled volumetric histopathology of human gliomas

Oakes-Klein J, Saghafi S, Roetzer-Pejrimovsky T, Fuchssteiner C, Grin K, Kiesel B, Körner L, Wöhrer A, Widhalm G, Dodt H.   +9 more
europepmc   +1 more source

Automated analysis of scattering-based light sheet microscopy images of anal squamous intraepithelial lesions. [PDF]

Biomed Opt Express
Kim Y, Zhao J, Liang B, Sugimura M, Marcelino K, Romero R, Nessaee A, Ocaya C, Lim K, Roe D, Khan MJ, Yang EJ, Kang D.   +12 more
europepmc   +1 more source

Frontiers in artificial intelligence-directed light-sheet microscopy for uncovering biological phenomena and multi-organ imaging. [PDF]

View (Beijing)
Zhu E, Li YR, Margolis S, Wang J, Wang K, Zhang Y, Wang S, Park J, Zheng C, Yang L, Chu A, Zhang Y, Gao L, Hsiai TK.   +13 more
europepmc   +1 more source

Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy. [PDF]

Nat Commun
Dibaji H, Kazemi Nasaban Shotorban A, Grattan RM, Lucero S, Schodt DJ, Lidke KA, Petruccelli J, Lidke DS, Liu S, Chakraborty T.   +9 more
europepmc   +1 more source