Results 11 to 20 of about 48,368 (252)

Genetic compensation response contributes to Pleurodeles waltl limb regeneration [PDF]

npj Regenerative Medicine
Hippo-Yap/Taz pathway is essential for tissue regeneration in multiple species. However, we found that in the highly regenerative salamanders, Yap knockout does not compromise the limb regeneration due to genetic compensation response (GCR). Specifically,
Binxu Yin, Changhao Yu, Yang Liu, Hao Cai, Wencheng Wu, Tingting Ye, Lei Wang, Lujia Xiao, Yi Zhu, Huaijuan Guo, Kun Zhang, Heng Wang   +11 more
doaj   +2 more sources

Post-amputation reactive oxygen species production is necessary for axolotls limb regeneration [PDF]

Frontiers in Cell and Developmental Biology, 2022
Introduction: Reactive oxygen species (ROS) represent molecules of great interest in the field of regenerative biology since several animal models require their production to promote and favor tissue, organ, and appendage regeneration.
Belfran Carbonell-M, Belfran Carbonell-M, Juliana Zapata Cardona, Jean Paul Delgado   +3 more
doaj   +2 more sources

Comparative multi-omic analysis reveals conserved and derived mechanisms of fin and limb regeneration [PDF]

Nature Communications
Comparative studies of vertebrate appendages offer a powerful framework for uncovering shared components of an ancestral regeneration toolkit. Here, we employed a multi-omics comparative approach leveraging the regenerative capacity of the axolotl ...
Josane F. Sousa, Gabriela Lima, Louise Perez, Hannah Schof, Igor Schneider   +4 more
doaj   +2 more sources

hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration [PDF]

Nature Communications
During organ regeneration, after the initial responses to injury, gene expression patterns similar to those in normal development are reestablished during subsequent morphogenesis phases. This supports the idea that regeneration recapitulates development
Aiko Kawasumi-Kita, Sang-Woo Lee, Daisuke Ohtsuka, Kaori Niimi, Yoshifumi Asakura, Keiichi Kitajima, Yuto Sakane, Koji Tamura, Haruki Ochi, Ken-ichi T. Suzuki, Yoshihiro Morishita   +10 more
doaj   +2 more sources

Dorsoventral-mediated Shh induction is required for axolotl limb regeneration [PDF]

eLife
Axolotls (Ambystoma mexicanum) exhibit a remarkable ability to regenerate limbs. Classical experiments have suggested that contact between cells derived from distinct orientations—dorsal, ventral, anterior, and posterior—within the regenerating blastema ...
Sakiya Yamamoto, Saya Furukawa, Ayaka Ohashi, Mayuko Hamada, Akira Satoh   +4 more
doaj   +2 more sources

Modeling proximalisation in axolotl limb regeneration. [PDF]

Sci Rep
Abstract The axolotl (Ambystoma mexicanum) possesses a remarkable ability to regenerate tissues. Following limb amputation, a blastema of progenitor cells forms, expands, and reconstructs all distal structures, implying that mature cells near the wound retain positional memory along the proximal–distal (PD) axis.
Arce H, Ceccarelli AS, Córdoba RC, Oliveira ACR, Yun MH, Chara O.   +5 more
europepmc   +3 more sources

Limb Regeneration in Amphibians: Immunological Considerations

Scientific World Journal, The, 2006
We review key aspects of what is known about limb regeneration in urodele and anuran amphibians, with a focus on the early events of the process that lead to formation of the regeneration blastema.
Anthony Mescher
exaly   +2 more sources

Wnt Signaling Coordinates the Expression of Limb Patterning Genes During Axolotl Forelimb Development and Regeneration

Frontiers in Cell and Developmental Biology, 2022
After amputation, axolotl salamanders can regenerate their limbs, but the degree to which limb regeneration recapitulates limb development remains unclear.
Alexander M. Lovely, Timothy J. Duerr, Qingchao Qiu, Santiago Galvan, S. Randal Voss, James R. Monaghan, James R. Monaghan   +6 more
doaj   +1 more source

Evi5 is required for Xenopus limb and tail regeneration

Frontiers in Cell and Developmental Biology, 2022
Amphibians such as salamanders and the African clawed frog Xenopus are great models for regeneration studies because they can fully regenerate their lost organs.
Li Yang, Youwei Chen, Huahua Liu, Yu Liu, Feng Yuan, Qianyan Li, Gufa Lin   +6 more
doaj   +1 more source

Accessories to Limb Regeneration [PDF]

Developmental Cell, 2016
In a recent issue of Nature, Nacu et al. (2016) identified FGF and HH ligands as interacting molecular influences that are necessary and sufficient to induce the formation of supernumerary limbs from blastemal tissue in axolotl salamanders.
Yanchao, Han, Kenneth D, Poss
openaire   +2 more sources