Results 21 to 30 of about 48,368 (252)
Single-cell transcriptomics technology and its application in limb regeneration research
生物医学转化, 2023 Salamanders have a strong ability to regenerate limbs, while this potential is progressively declined in frogs during development. With evolution, adults of humans and other mammals completely lose the ability to regenerate limbs.
Yin Fuling +3 more
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Limb regeneration revisited [PDF]
Journal of Biology, 2009 The investigation of vertebrate limb regeneration, a favorite topic of early developmental biologists, is enjoying a renaissance thanks to recently developed molecular and genetic tools, as indicated in recent papers in BMC Biology and BMC Developmental Biology. Classical experiments provide a rich context for interpreting modern functional studies.
Whited, Jessica, Tabin, Clifford
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Retinoic Acid Receptors and the Control of Positional Information in the Regenerating Axolotl Limb
Cells, 2021 We know little about the control of positional information (PI) during axolotl limb regeneration, which ensures that the limb regenerates exactly what was amputated, and the work reported here investigates this phenomenon.
Trey Polvadore, Malcolm Maden
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Cell Regeneration, 2021 Background Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration. However, the expression and function of Mc4r in the mouse limb and digit has not been fully investigated.
Hanqian Xu +6 more
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Ecology and Evolution, 2023 Regeneration of lost appendages is a gradual process in many species, spreading energetic costs of regeneration through time. Energy allocated to the regeneration of lost appendages cannot be used for other purposes and, therefore, commonly elicits ...
Blaine D. Griffen +6 more
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Multi-species atlas resolves an axolotl limb development and regeneration paradox
Nature Communications, 2023 Humans and other tetrapods are considered to require apical-ectodermal-ridge (AER) cells for limb development, and AER-like cells are suggested to be re-formed to initiate limb regeneration.
Jixing Zhong +6 more
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Ectopic Fgf signaling induces the intercalary response in developing chicken limb buds
Zoological Letters, 2018 Background Intercalary pattern formation is an important regulatory step in amphibian limb regeneration. Amphibian limb regeneration is composed of multiple steps, including wounding, blastema formation, and intercalary pattern formation.
Aki Makanae, Akira Satoh
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eLife, 2022 The expression of fibroblast growth factors (Fgf) ligands in a specialized epithelial compartment, the Apical Ectodermal Ridge (AER), is a conserved feature of limb development across vertebrate species.
Giacomo L Glotzer +2 more
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Regeneration potency of mouse limbs [PDF]
Development, Growth & Differentiation, 2007 Mammalians have a low potency for limb regeneration compared to that of amphibians. One explanation for the low potency is the deficiency of cells for regenerating amputated limbs in mammals. Amphibians can form a blastema with dedifferentiated cells, but mammals have few such cells.
Hideki, Masaki, Hiroyuki, Ide
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Frontiers in Physiology, 2021 Therapeutic implementation of human limb regeneration is a daring aim. Studying species that can regrow their lost appendages provides clues on how such a feat can be achieved in mammals.
Can Aztekin
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