Results 171 to 180 of about 4,052 (247)

Limonin, a novel AMPK activator, protects against LPS-induced acute lung injury.

International Immunopharmacology, 2023
AMP-activated protein kinase (AMPK) activation plays crucial roles in the treatment of many oxidative stress- and inflammation-induced diseases, including acute lung injury (ALI).
Hui Liang, Gaoli Liu, Qinglu Fan, Zhihao Nie, S. Xie, Renquan Zhang   +5 more
semanticscholar   +1 more source

Evaluation of the Antioxidant Capacity of Limonin, Nomilin, and Limonin Glucoside

Journal of Agricultural and Food Chemistry, 2006
The antioxidant capacity (AOC) of three representative citrus limonoids, limonin, nomilin, and limonin glucoside, was examined by the oxygen radical absorbance capacity (ORAC), Trolox equivalent antioxidant capacity (TEAC), beta-carotene-linoleic acid bleaching, and 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assays.
Andrew P, Breksa, Gary D, Manners
openaire   +2 more sources

Pectin based hydrogel with covalent coupled doxorubicin and limonin loading for lung tumor therapy.

Colloids and Surfaces B: Biointerfaces, 2023
Self-healing hydrogels have shown great application potential in drug delivery for anti-tumor therapy and tissue engineering. In this research, Doxorubicin (DOX) was coupled onto the oxidized pectin (pec-Ald) to prepare DOX grafted pec-AD and used to ...
Danyang Chen, Xiangbo Ma, Jingjing Zhu, Yong Wang, Shuai Guo, Jianglei Qin   +5 more
semanticscholar   +1 more source

Total Synthesis of Limonin

Angewandte Chemie International Edition, 2015
AbstractLimonoids are highly oxygenated C13α‐triterpenes and common secondary metabolites. Several hundred congeners have been isolated to date. The first total synthesis of (±)‐limonin, the flagship congener of the limonoids, is now reported and features 1) a tandem radical cyclization generating the BCD ring system with the C13α configuration that is
Shuji, Yamashita, Akito, Naruko, Yuki, Nakazawa, Le, Zhao, Yujiro, Hayashi, Masahiro, Hirama   +5 more
openaire   +2 more sources

Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats.

International Immunopharmacology, 2023
Parkinson's disease (PD) is a neurodegenerative disorder that occurs most frequently in middle-aged and elderly people. It is characterized by an insidious onset and a complex etiology, and no effective treatment has been developed.
Xiyu Gao, Dewei He, Yanting Liu, Mingchi Cui, Zhe Li, Jie Li, Yuan He, Hefei Wang, B. Ye, Shoupeng Fu, Dianfeng Liu   +10 more
semanticscholar   +1 more source

Self-healing pectin/cellulose hydrogel loaded with limonin as TMEM16A inhibitor for lung adenocarcinoma treatment.

International Journal of Biological Macromolecules, 2022
Lung cancer as one of the highest incident malignant tumors did not receive satisfactory chemotherapy due to lack of specific drug targets and targeted drugs.
Limin Chang, Ruixue Chang, Jiafu Shen, Yong Wang, Hongzan Song, Xianjiang Kang, Youliang Zhao, Shuai Guo, Jianglei Qin   +8 more
semanticscholar   +1 more source

The structure of limonin

Experientia, 1960
Die Struktur desepi-Limonol-jodoacetates (C26H31O8) COCH2I, wurde durch dreidimensionale Rontgenanalyse bestimmt. Es gelang, die Lage samtlicher Atome in zwei kristallographisch unabhangigen, jedoch chemisch identischen Molekeln zu ermitteln. Dieses Resultat stellt eine vollstandige Bestimmung der Konstitution und der Stereochemie des Limonins dar.
S. Arnott, A. W. Davie, J. M. Robertson, G. A. Sim, D. G. Watson   +4 more
openaire   +1 more source

Dietary limonin ameliorates heart failure with preserved ejection fraction by targeting ferroptosis via modulation of the Nrf2/SLC7A11/GPX4 axis: an integrated transcriptomics and metabolomics analysis.

Food & Function
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome characterized by hypertension, metabolic disorders, and impaired diastolic function, with limited therapeutic options. Recent studies have highlighted the role of ferroptosis in
Xiaoqi Wei, Xinyi Fan, Wangjing Chai, Jinling Xiao, Jiong Zhao, Aolong He, Xian-Lung Tang, Fanghe Li, Shuzhen Guo   +8 more
semanticscholar   +1 more source

Limonin: Advances in extraction, synthesis, pharmacological mechanisms, and structural optimization for therapeutic potential.

Fitoterapia
Limonin, a highly oxygenated nor-triterpenoid phytochemical abundant in Citrus plants, has attracted considerable attention because of its diverse pharmacological properties.
Xianghui Meng, Zhichao Xi, Xinwei Chen, D. Green, Yunhao Zhou, Y. Xian, Hongmei Zhang   +6 more
semanticscholar   +1 more source

Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1

Phytomedicine, 2020
BACKGROUND Limonin, a bioactive compound from citrus plants, exerts antioxidant activities, however its therapeutic potential in acetaminophen (APAP)-induced hepatotoxicity remains unclear. PURPOSE Our study aims to investigate the protective effect of
Yang Sun, Qi Zhang
exaly   +2 more sources