Results 91 to 100 of about 6,338,079 (289)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Challenging Case of Miliary Tuberculosis in Pregnancy

International Journal of Mycobacteriology
Miliary tuberculosis (TB) is an uncommon yet severe condition that can pose substantial risks to pregnant women and their unborn child. This case study describes a 22-year-old pregnant female at 23 weeks of gestation presented with breathlessness, fever ...
Anuja Singh, Farha Siddiqui, Anand Kumar Maurya, Shashank Purwar, Saurabh Saigal   +4 more
doaj   +1 more source

GAMBARAN PENDERITA TB-XDR BERDASARKAN PEMERIKSAAN LINE PROBE ASSAY LINI DUA DI RSUP PERSAHABATAN PERIODE JANUARI-JULI 2022 [PDF]

, 2022
GAMBARAN PENDERITA TB-XDR BERDASARKAN PEMERIKSAAN LINE PROBE ASSAY LINI DUA DI RSUP PERSAHABATAN PERIODE JANUARI-JULI 2022 Rizka Anggun Hadiyani 1804034062 Resiko kejadian TB dipengaruhi oleh banyak faktor, diantaranya adalah faktor usia, jenis ...
Sri, Wahyuni Handayani, Rizka, Anggun Hadiyani, Engla, Merizka   +2 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Importance of Detection of Isoniazid and Rifampicin Mono Drug Resistance and Determining Rate of MDR-TB in Smear Positive Sputum Samples from a Tertiary Care Hospital of West U.P. India

Journal of Pure and Applied Microbiology, 2019
Anti-tubercular therapy is one of the effective strategies used to control tuberculosis, so, a planned and accurate treatment regimen is of utmost importance, but number of cases are being treated as MDR on the basis of rifampicin mono resistance.
Sana Nudrat, Umar Farooq, Mazhar Maqsood
doaj   +1 more source

Enzymatic Synthesis of a Fluorogenic Reporter Substrate and a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation [PDF]

, 2019
We report a straight-forward enzymatic synthesis of the 4-methylumbelliferyl glycoside of a complex-type oligosaccharide substrate for core-fucosylation.
David, Kwan, David Kwan (8196099), Maxim, Soroko, Maxim Soroko (8196100)   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Genetic characterization of Mycobacterium tuberculosis complex isolates circulating in Abuja, Nigeria

Infection and Drug Resistance, 2018
Barbara Molina-Moya,1,2 Saddiq T Abdurrahman,3 Laura I Madukaji,4 Michel Kiréopori Gomgnimbou,5,6 Lizania Spinasse,5 Meissiner Gomes-Fernandes,1,2,7 Harrison Magdinier Gomes,5 Sarah Kacimi,5 Russell Dacombe,8 John S Bimba,4 Lovett Lawson,4 ...
Molina-Moya B, Abdurrahman ST, Madukaji LI, Gomgnimbou MK, Spinasse L, Gomes-Fernandes M, Gomes HM, Kacimi S, Dacombe R, Bimba JS, Lawson L, Sola C, Cuevas LE, Dominguez J   +13 more
doaj  

Evaluation of the AID ESBL line probe assay for rapid detection of extended-spectrum β-lactamase (ESBL) and KPC carbapenemase genes in Enterobacteriaceae [PDF]

, 2017
Objectives This study aimed at evaluating the AID ESBL line probe assay for the detection of extended-spectrum β-lactamase (ESBL) and KPC carbapenemase genes in Enterobacteriaceae.
Bloemberg, Guido V., Polsfuss, Silke, Meyer, Vera, Böttger, Erik C., Hombach, Michael   +4 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source