Results 111 to 120 of about 6,338,079 (289)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 2016 The impact of a line probe assay based diagnostic algorithm on time to treatment initiation and treatment outcomes for multidrug resistant TB patients in Arkhangelsk Region ...
A Detjen (13570279) +13 more
core
Effectiveness of the Line Probe Assay Compared with Conventional Culture for Detecting Second-Line Anti-Tuberculosis Drug Resistance [PDF]
Drug-resistant tuberculosis (MDR-TB and rifampicin-resistant TB) is a major challenge in TB control in Indonesia. Rapid detection of second-line anti-TB drug resistance is crucial for timely initiation of therapy.
Nurhidayanti, Nurhidayanti +1 more
core +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Establishing proof of concept for utility of Trueprep<sup>®</sup>-extracted DNA in line-probe assay testing. [PDF]
Int J Tuberc Lung Dis, 2023 Rajendran P +14 more
europepmc +1 more source
The role of line probe assays in the Xpert MTB/RIF Ultra era
Journal of Laboratory and Precision Medicine, 2017 Tuberculosis (TB) remains an important public health problem with an estimated 10.4 million new cases diagnosed in 2015 (1). Of these, approximately 4.3 million cases went undiagnosed or unreported, posing a major hurdle to the eradication of TB (1). The control of TB is further threatened by the HIV epidemic and the emergence and spread of multidrug ...
Annelies Van Rie, Margaretha De Vos
openaire +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
, 2015 Introduction: A sensitive, rapid and accurate laboratory diagnostic method is essential for detection of tuberculosis and its drug resistance. However, using conventional techniques for detection of acidfast bacilli and mutations conferring resistance ...
Chaburte, Chala
core +1 more source