Results 121 to 130 of about 6,338,079 (289)

Species identification and drug susceptibility testing of non-tuberculous mycobacteria by Line Probe Assay in Lambaréné, Gabon-a cross-sectional study. [PDF]

BMC Infect Dis, 2023
Ndanga MED, Abdul JBPAA, Edoa JR, Ibinda GARM, Adegbite BR, Mevyann RC, Biyogho CM, Mahoumbou J, Manguinga S, Roguet NM, Lell B, Kremsner PG, Alabi AS, Grobusch MP, Adegnika AA.   +14 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Diagnosis of tuberculosis from smear-negative presumptive TB cases using Xpert MTB/Rif assay: a cross-sectional study from Nepal

BMC Infectious Diseases, 2019
Background In most developing countries, smear-negative pulmonary TB (SNPT) often gets missed from the diagnosis of consideration, though it accounts 30–65% of total PTB cases, due to deficient or inaccessible molecular diagnostic modalities. Methods The
Priyatam Khadka, Januka Thapaliya, Ramesh Bahadur Basnet, Gokarna Raj Ghimire, Jyoti Amatya, Basista Parsad Rijal   +5 more
doaj   +1 more source

To Test or Not? Xpert MTB/RIF as an Alternative to Smear Microscopy to Guide Line Probe Assay Testing for Drug-Resistant Tuberculosis. [PDF]

J Clin Microbiol, 2023
Pillay S, de Vos M, Sohn H, Ghebrekristos Y, Dolby T, Warren RM, Theron G.   +6 more
europepmc   +1 more source

Performance of Line Probe Assay (MTBDRplus) in the Detection of Drug Resistance Tuberculosis

, 2019
ABSTRACT Objective/purpose: The development of multidrug resistant tuberculosis and the emergence of extensively and totally drug resistant TB worsen the overall TB control programs. The World Health Organization validates the use of Line Probe Assay (LPA) for rapid detection of MDR-TB. The study evaluates the performance of LPA (MTBDRplus) compared to
ABUBAKAR TUKUR DAWAKIN KUDU, AISHATU AMINU IBRAHIM, ABDULHADI SALE KUMURYA, AMINU BASHIR MUHAMMAD, MURTALA RABIU, JAMIU OLAYINKA OLABAMIJI, BASHIR USAINI RINGIM, UMAR ALIYU AHMAD   +7 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Evaluation of extracts from used Xpert MTB/RIF cartridges for detection of resistance to second-line anti-tuberculosis drugs in patients with multidrug-resistant tuberculosis in Ethiopia

BMC Microbiology
Background Early and accurate diagnosis of drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug ...
Tilahun Ketema, Mulualem Tadesse, Zegeye Bonsa, Getu Balay, Wakjira Kebede, Mekidim Mekonnen, Gemeda Abebe   +6 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Diagnostic performance of the GenoType MTBDRplus VER 2.0 line probe assay for the detection of isoniazid resistant Mycobacterium tuberculosis in Ethiopia. [PDF]

PLoS One, 2023
Moga S, Bobosha K, Fikadu D, Zerihun B, Diriba G, Amare M, Kempker RR, Blumberg HM, Abebe T.   +8 more
europepmc   +1 more source