Results 101 to 110 of about 6,338,079 (289)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Longitudinal Use of a Line Probe Assay for Human Immunodeficiency Virus Type 1 Protease Predicts Phenotypic Resistance and Clinical Progression in Patients Failing Highly Active Antiretroviral Therapy

, 2002
An observational study assessed the longitudinal use of a new line probe assay for the detection of protease mutations. Probe assays for detection of reverse transcriptase (Inno-LiPA HIV-1 RT; Innogenetics) and protease (prototype kit Inno-LiPA HIV ...
Vic Arendt, Jean-Claude Schmit, François Schneider, Isabelle Robert, Thérèse Staub, Robert Hemmer, Jean Servais, Christine Lambert, Jean-Marc Plesséria, Elodie Fontaine   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Multidrug-resistant Tuberculosis Detection, Latvia

Emerging Infectious Diseases, 2005
To improve multidrug-resistant tuberculosis (MDR-TB) detection, we successfully introduced the rpoB gene mutation line probe assay into the national laboratory in Latvia, a country with epidemic MDR-TB.
Girts Skenders, Alicia M. Fry, Inga Prokopovica, Silvija Greckoseja, Lonija Broka, Beverly Metchock, Timothy H. Holtz, Charles D. Wells, Vaira Leimane   +8 more
doaj   +1 more source

Annual trends in the time from the first institution visit to initiation of appropriate treatment, and the proportion of patients who underwent line probe assays or Xpert MTB/RIF assays.

, 2019
INH, isoniazid; LPA, line probe assay; PNUH, Pusan National University Hospital; RIF, rifampin. *Data are presented as the median.
Kwangha Lee (3168099), Jeongha Mok (6238151), Kyu Min Lee (6635798), Mi-Hyun Kim (320292), Seyeon Park (113117), Min Ki Lee (3092682), Eun-Jung Jo (474683), Hye-Kyung Park (540865), Insu Kim (1509799), Jung Seop Eom (667471), Ki Uk Kim (3168096)   +10 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

RAPID DETECTION OF MULTI DRUG RESISTANCE AMONG MULTI DRUG RESISTANT TUBERCULOSIS SUSPECTS USING LINE PROBE ASSAY [PDF]

, 2017
Objective: GenoType MTBDRplus line probe assay (LPA) is developed for performing drug susceptibility testing (DST) for Rifampicin (RIF) and isoniazid in sputum specimens from smear-positive pulmonary tuberculosis (TB) patients and revised national TB ...
Saini, Sanjeev, Bhardwaj, Uma, Kk, Chopra, Ahmed, Vasim, Dubey, Manoj Kumar, Sidiq, Zeeshan, Dwivedi, Kaushal Kumar, Hanif, M, Khanna, Ashwani, Sharma, Srashty, Vashistha, Himanshu   +10 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

RAPID DETECTION OF MULTI DRUG RESISTANCE AMONG MULTI DRUG RESISTANT TUBERCULOSIS SUSPECTS USING LINE PROBE ASSAY

, 2016
Objective: GenoType MTBDRplus line probe assay (LPA) is developed for performing drug susceptibility testing (DST) for Rifampicin (RIF) andisoniazid in sputum specimens from smear-positive pulmonary tuberculosis (TB) patients and revised national TB ...
M Hanif, Himanshu Vashistha, Chopra Kk, Uma Bhardwaj, Ashwani Khanna ., Kaushal Kumar Dwivedi, Vasim Ahmed, Sanjeev Saini, Srashty Sharma, Zeeshan Sidiq, Manoj Kumar Dubey   +10 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source