Results 211 to 220 of about 63,855 (231)
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International Journal of Antimicrobial Agents, 2023
BACKGROUND Linezolid is a broad-spectrum antimicrobial but toxicity limits it use. This study aimed to evaluate linezolid toxicity in a large multicentre cohort. Secondary objectives were to identify factors contributing to toxicity, including the impact
Suman Adhikari, Yuen Su, Cindy Lau
exaly +2 more sources
BACKGROUND Linezolid is a broad-spectrum antimicrobial but toxicity limits it use. This study aimed to evaluate linezolid toxicity in a large multicentre cohort. Secondary objectives were to identify factors contributing to toxicity, including the impact
Suman Adhikari, Yuen Su, Cindy Lau
exaly +2 more sources
Reactions weekly, 2020 Linezolid is a synthetic oxazolidinone antimicrobial drug. It is indicated for gram-positive infections and approved for the treatment of bacterial pneumonia, skin and skin structure infections, and vancomycin-resistant enterococcal (VRE) infections ...
Azzouz, Angela, Preuss, Charles V
semanticscholar +3 more sources
Expert Review of Clinical Pharmacology, 2023
Introduction Linezolid can cause serious adverse effects including thrombocytopenia and anemia. Here, we focus specifically on linezolid-related hematological toxicity in adult patients requiring prolonged drug treatment.
D. Cattaneo, D. Marriott, C. Gervasoni
semanticscholar +1 more source
Introduction Linezolid can cause serious adverse effects including thrombocytopenia and anemia. Here, we focus specifically on linezolid-related hematological toxicity in adult patients requiring prolonged drug treatment.
D. Cattaneo, D. Marriott, C. Gervasoni
semanticscholar +1 more source
Clinical Infectious Diseases, 2022
Group A Streptococcus (GAS) necrotizing soft tissue infections and toxic shock syndrome remain high-mortality conditions. In vitro and animal model data, as well as multiple observational studies, suggest adjunctive clindamycin (i.e., given with a beta ...
Nicolás W Cortés-Penfield +1 more
semanticscholar +1 more source
Group A Streptococcus (GAS) necrotizing soft tissue infections and toxic shock syndrome remain high-mortality conditions. In vitro and animal model data, as well as multiple observational studies, suggest adjunctive clindamycin (i.e., given with a beta ...
Nicolás W Cortés-Penfield +1 more
semanticscholar +1 more source
Therapeutic Drug Monitoring, 2020
Linezolid is an antibiotic used to treat infections caused by drug-resistant gram-positive organisms, including vancomycin-resistant Enterococcus faecium, multi-drug resistant Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus. The
G. Rao +5 more
semanticscholar +1 more source
Linezolid is an antibiotic used to treat infections caused by drug-resistant gram-positive organisms, including vancomycin-resistant Enterococcus faecium, multi-drug resistant Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus. The
G. Rao +5 more
semanticscholar +1 more source
Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes
Journal of antibiotics (Tokyo. 1968)Linezolid binds to the 50S subunit of the bacterial ribosome, inhibiting bacterial protein synthesis by preventing the formation of the initiation complex.
Wenjing Yang +3 more
semanticscholar +1 more source
Linezolid Resistance in Staphylococci
Pharmaceuticals, 2010 Linezolid, the first oxazolidinone to be used clinically, is effective in the treatment of infections caused by various Gram-positive pathogens, including multidrug resistant enterococci and methicillin-resistant Staphylococus aureus.
Dafne Bongiorno +2 more
exaly +2 more sources
International Journal of Antimicrobial Agents, 2021
OBJECTIVE Data supporting oral step-down therapy in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI) are sparse; linezolid offers potential in this setting.
Samantha D. Yeager +4 more
semanticscholar +1 more source
OBJECTIVE Data supporting oral step-down therapy in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI) are sparse; linezolid offers potential in this setting.
Samantha D. Yeager +4 more
semanticscholar +1 more source
Linezolid-associated serotonin toxicity: a systematic review
European Journal of Clinical Pharmacology, 2023F. Elbarbry, N. Moshirian
semanticscholar +1 more source
Linezolid pharmacokinetics: a systematic review for the best clinical practice
European Journal of Clinical Pharmacology, 2022Shima Heidari, H. Khalili
semanticscholar +1 more source