Results 101 to 110 of about 8,342 (214)

Integrating Multimodal AI Techniques and MRI Preprocessing for Enhanced Diagnosis of Alzheimer’s Disease: Clinical Applications and Research Horizons

IEEE Access
A progressive neurological disorder, Alzheimer’s disease has a significant social and economic impact and has become more problematic for world health.
Bandaru A Chakravarthi, Gandla Shivakanth   +1 more
doaj   +1 more source

A Multimodal Machine Learning Model for Framingham Risk Score–Based Cardiovascular Risk Stratification in Patients With Obstructive Sleep Apnea

Journal of Sleep Research, EarlyView.
ABSTRACT Machine learning provides a powerful tool to capture complex, nonlinear patterns in biomedical data and enhance precision risk stratification. In this study, we applied a multilayer perceptron (MLP) framework to classify Framingham Risk Score–based cardiovascular risk categories in patients with obstructive sleep apnea (OSA).
Feng Zhao, Yin Li, Chenyang Li, Huajun Xu, Enhui Zhou, Weijun Huang, Huaming Zhu, Jian Guan, Hongliang Yi, Jianyin Zou, Nutan Chen   +10 more
wiley   +1 more source

Metagenomic Evaluation of Oral Microbiota in Patients Affected by Oral Lichen Planus: A Pilot Study

Oral Diseases, EarlyView.
ABSTRACT Objective To characterize the oral bacterial and fungal microbiota of symptomatic oral lichen planus patients undergoing topical corticosteroid therapy and to explore microbial patterns potentially associated with subsequent oral candidiasis. Methods Twelve patients with clinically and histologically confirmed OLP were enrolled.
A. Dormiente, L. Mancabelli, M. Ventura, G. Longhi, G. Mergoni, M. Manfredi   +5 more
wiley   +1 more source

Voice, Speech, and Large Language Models in Neurology: From Acoustic Biomarkers to Conversational AI

Computation
Background: Speech models (wav2vec 2.0, HuBERT, Whisper), large language models (GPT, LLaMA), and conversational AI have expanded computational speech analysis from handcrafted acoustic features to dialogue-based neurological assessment.
Shahar Shelly
doaj   +1 more source

Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa

Oral Diseases, EarlyView.
ABSTRACT Objective To analyze the nuclear abnormalities of cytotoxicity—karyorrhexis (KR), karyolysis (KL), and pyknosis (PN)—and genotoxicity—micronucleus (MN) in exfoliated cells from different sites of the oral mucosa in patients with Epidermolysis Bullosa (EB) and a control group.
Ana Carolina Sias Franco Franzosi, Rebeca Ferreira Badaró, Lucas Fernandes Leal, Rosalie Matuk Fuentes Torrelio, Willian Grassi Bautz, Leticia Nogueira da Gama‐de‐Souza   +5 more
wiley   +1 more source

Integrating NLP and LLMs to discover biomarkers and mechanisms in Alzheimer's disease

SLAS Technology
Alzheimer's disease (AD) is a progressive neurological condition characterized by cognitive decline, memory loss, and aberrant behaviour. It affects millions of people globally and is one of the main causes of dementia.
JinTao Song, JunJie Huang, RuiLi Liu
doaj   +1 more source

Efficacy of a Hyaluronic Acid‐Based Gel Versus 0.20% Chlorhexidine in Nonsurgical Periodontal Therapy: A Single‐Blind Randomized Clinical Trial

Oral Diseases, EarlyView.
ABSTRACT Objective To compare the adjunctive efficacy of a hyaluronic acid (HA) gel with 0.20% chlorhexidine (CHX) during nonsurgical periodontal therapy in periodontal patients over 6 months. Methods A single‐blind, randomized, controlled trial included 40 healthy, nonsmoking adults with periodontitis.
Andrea Scribante, Maurizio Pascadopoli, Matteo Pellegrini, Karyna Chekal, Andrea Butera   +4 more
wiley   +1 more source

Oxidative Stress–Driven Alterations in FoxO‐1 and MMP‐9 Activity in Smoking‐Associated Periodontitis

Oral Diseases, EarlyView.
ABSTRACT Objectives Smoking disrupts oxidative balance and is a major risk factor for periodontitis. Forkhead box protein O‐1 (FoxO‐1) regulates antioxidant defense, yet its contribution to smoking‐associated periodontal breakdown is unclear. This cross‐sectional case–control study assessed reactive oxygen species (ROS), matrix metalloproteinase‐9 (MMP‐
Fatma Oner, Fatma Soysal, Ceren Gokmenoglu, Muhittin A. Serdar, Zeliha Guney   +4 more
wiley   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

Retrospective Analysis of Pseudotumor of the Hip: Clinical Management and Outcomes

Orthopaedic Surgery, EarlyView.
The surgical revision treatment of patients affected by pseudotumor guarantees a good functional result with a low risk of failure of the new implant. However, pseudotumor requires a systematic and efficient surgical approach to be quickly and successfully resolved.
Roberta Laranga, Luca Cevolani, Eric Lodewijk Staals, Anna Mammone, Laura Campanacci, Barbara Dozza, Davide Maria Donati, Giuseppe Bianchi   +7 more
wiley   +1 more source