Results 121 to 130 of about 8,531 (253)

Blood Astrocyte Biomarkers in Alzheimer Disease

BACKGROUND AND OBJECTIVES: Neuroinflammation, particularly early astrocyte reactivity, is a significant driver of Alzheimer disease (AD) pathogenesis.
Italiano, D, Holper, S, Watson, R, Churilov, L, Loveland, P, Yassi, N   +5 more
core   +1 more source

Abstract A68: What do they do? The art and science of patient navigation among underserved Latina minorities: The significance of language

, 2015
Background: Patient Navigation has evolved to reduce cancer health disparities by eliminating barriers to diagnosis, treatment, and survivorship services. Attempts have been made to describe barriers to care and navigator actions.
Talavera, Gregory A., Maria Fernandez, Holden, Alan E. C., Kipling Gallion, Gallion, Kipling, Munoz, Edgar, Perez-Stable, Eliseo J., Penedo, Frank, Carrillo, J. Emilio, Fernandez, Maria, Eliseo J. Perez-Stable, Edgar Munoz, Ramirez, Amelie G., Frank Penedo, Miguel, Sandra San, J. Emilio Carrillo, Amelie G. Ramirez, Alan E. C. Holden, Sandra San Miguel, Gregory A. Talavera   +19 more
core   +1 more source

Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa

Oral Diseases, EarlyView.
ABSTRACT Objective To analyze the nuclear abnormalities of cytotoxicity—karyorrhexis (KR), karyolysis (KL), and pyknosis (PN)—and genotoxicity—micronucleus (MN) in exfoliated cells from different sites of the oral mucosa in patients with Epidermolysis Bullosa (EB) and a control group.
Ana Carolina Sias Franco Franzosi, Rebeca Ferreira Badaró, Lucas Fernandes Leal, Rosalie Matuk Fuentes Torrelio, Willian Grassi Bautz, Leticia Nogueira da Gama‐de‐Souza   +5 more
wiley   +1 more source

Efficacy of a Hyaluronic Acid‐Based Gel Versus 0.20% Chlorhexidine in Nonsurgical Periodontal Therapy: A Single‐Blind Randomized Clinical Trial

Oral Diseases, EarlyView.
ABSTRACT Objective To compare the adjunctive efficacy of a hyaluronic acid (HA) gel with 0.20% chlorhexidine (CHX) during nonsurgical periodontal therapy in periodontal patients over 6 months. Methods A single‐blind, randomized, controlled trial included 40 healthy, nonsmoking adults with periodontitis.
Andrea Scribante, Maurizio Pascadopoli, Matteo Pellegrini, Karyna Chekal, Andrea Butera   +4 more
wiley   +1 more source

Integrating NLP and LLMs to discover biomarkers and mechanisms in Alzheimer's disease

SLAS Technology
Alzheimer's disease (AD) is a progressive neurological condition characterized by cognitive decline, memory loss, and aberrant behaviour. It affects millions of people globally and is one of the main causes of dementia.
JinTao Song, JunJie Huang, RuiLi Liu
doaj   +1 more source

Lexical diversity and mild cognitive impairment

, 2019
This paper explores the role that various lexical-based measures play for differentiating between individuals with mild forms of cognitive impairment (MCI) and healthy controls (HC).
Kokkinakis, Dimitrios,, Johansson, Sofie,, Lundholm Fors, Kristina,, Antonsson, Malin,   +3 more
core   +1 more source

Oxidative Stress–Driven Alterations in FoxO‐1 and MMP‐9 Activity in Smoking‐Associated Periodontitis

Oral Diseases, EarlyView.
ABSTRACT Objectives Smoking disrupts oxidative balance and is a major risk factor for periodontitis. Forkhead box protein O‐1 (FoxO‐1) regulates antioxidant defense, yet its contribution to smoking‐associated periodontal breakdown is unclear. This cross‐sectional case–control study assessed reactive oxygen species (ROS), matrix metalloproteinase‐9 (MMP‐
Fatma Oner, Fatma Soysal, Ceren Gokmenoglu, Muhittin A. Serdar, Zeliha Guney   +4 more
wiley   +1 more source

Digital biomarkers of emotion processes associated with Posttraumatic Stress Disorder

The development, course and treatment of Posttraumatic Stress Disorder (PTSD) has been shown to be impacted by a range of emotion processes, which are primarily measured using self-report scales.
Meaney, Tomas
core   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, EarlyView.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

The oral microbiota and periodontal health in orthodontic patients

Periodontology 2000, EarlyView.
Abstract The oral microbiota develops within the first 2 years of childhood and becomes distinct from the parents by 4 years‐of‐age. The oral microbiota plays an important role in the overall health/symbiosis of the individual. Deviations from the state of symbiosis leads to dysbiosis and an increased risk of pathogenicity.
Brandon W. Peterson, Geerten‐Has Tjakkes, Anne‐Marie Renkema, David J. Manton, Yijin Ren   +4 more
wiley   +1 more source