Results 41 to 50 of about 8,531 (253)

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review

Frontiers in Neurology, 2018
Primary progressive aphasias (PPA) are neurodegenerative diseases clinically characterized by an early and relatively isolated language impairment. Three main clinical variants, namely the nonfluent/agrammatic variant (nfvPPA), the semantic variant ...
Maxime Montembeault, Maxime Montembeault, Maxime Montembeault, Simona M. Brambati, Simona M. Brambati, Maria Luisa Gorno-Tempini, Raffaella Migliaccio, Raffaella Migliaccio   +7 more
doaj   +1 more source

Learning Linguistic Biomarkers for Predicting Mild Cognitive Impairment using Compound Skip-grams

CoRR, 2015
Predicting Mild Cognitive Impairment (MCI) is currently a challenge as existing diagnostic criteria rely on neuropsychological examinations. Automated Machine Learning (ML) models that are trained on verbal utterances of MCI patients can aid diagnosis.
Sylvester Olubolu Orimaye, Kah Yee Tai, Jojo Sze-Meng Wong, Chee Piau Wong   +3 more
openaire   +2 more sources

Reference Data for Attentional, Executive, Linguistic, and Visual Processing Tests Obtained from Cognitively Healthy Individuals with Normal Alzheimer’s Disease Cerebrospinal Fluid Biomarker Levels

Journal of Alzheimer’s Disease, 2023
Background: Conventional neuropsychological norms likely include cognitively unimpaired (CU) individuals with preclinical Alzheimer’s disease (AD) pathology (amyloid-β, tau, and neurodegeneration) since they are based on cohorts without AD biomarkers data.
López-Martos, David, Brugulat-Serrat, Anna, Cañas-Martínez, Alba, Canals-Gispert, Lidia, Marne, Paula, Gramunt, Nina, Suárez-Calvet, Marc, Milà-Alomà, Marta, Minguillon, Carolina, Fauria, Karine, Zetterberg, Henrik, Blennow, Kaj, Gispert, Juan Domingo, Molinuevo, José Luis, Grau-Rivera, Oriol, Sánchez-Benavides, Gonzalo, ALFA study   +16 more
openaire   +3 more sources

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

From Label‐Free Multiphoton Imaging to Pathological Reports: A Vision‐Language Breast Cancer Margin Pathological Diagnosis System

Advanced Science, EarlyView.
MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang, Jingze Su, Xiahui Han, Deyong Kang, Xiao Zhang, Fei Xu, Changzu Liu, Junlin Pan, Xingfu Wang, Qiaohui Zhan, Aimin Wang, Feng Huang, Heping Cheng, Wenxi Liu, Ruolan Lin, Jianxin Chen   +15 more
wiley   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Voice Analysis of Cancer Experiences Among Patients With Breast Cancer: VOICE-BC

Journal of Patient Experience, 2021
Patient experience literature in early-stage breast cancer (eBC) is limited. This study used a mixed-methods approach to examine patient conversations from public online forums to identify and evaluate eBC-related themes.
Ernest H Law, Maria J Auil, Patricia A Spears, Kiersten Berg, Randall Winnette   +4 more
doaj   +1 more source

Utilizing Instagram Data to Identify Usage Patterns Associated With Schizophrenia Spectrum Disorders

Frontiers in Psychiatry, 2021
Background and Objectives: Prior research has successfully identified linguistic and behavioral patterns associated with schizophrenia spectrum disorders (SSD) from user generated social media activity.
Katrin Hänsel, Katrin Hänsel, Katrin Hänsel, Inna Wanyin Lin, Michael Sobolev, Michael Sobolev, Michael Sobolev, Whitney Muscat, Sabrina Yum-Chan, Sabrina Yum-Chan, Munmun De Choudhury, John M. Kane, John M. Kane, John M. Kane, Michael L. Birnbaum, Michael L. Birnbaum, Michael L. Birnbaum   +16 more
doaj   +1 more source