Results 61 to 70 of about 8,342 (214)

Speech and Deep Brain Stimulation in Parkinson's Disease, Essential Tremor, and Dystonia: A Systematic Review and Meta‐analysis

Movement Disorders, EarlyView.
Abstract Deep brain stimulation (DBS) effectively treats motor symptoms in movement disorders but often compromises speech through incompletely defined mechanisms. We conducted a PROSPERO‐registered systematic review and meta‐analysis of publications through August 2024 (CRD42024527738).
Elina Tripoliti, Takashi Tsuboi, Michael T. Barbe, Mario Sousa, Julie Barkmeier‐Kraemer, Hannah Jergas, Gaia Arno, Nicole Buie, Mikayla Day, Petr Krýže, Jayson R. Nelson, Aaron E.L. Warren, Shervin Rahimpour, Jan Rusz, Paul Krack, Kristina Simonyan   +15 more
wiley   +1 more source

Physical Activity and Exercise for People with Parkinson's Disease: The Past, Present, and Future

Movement Disorders, EarlyView.
Abstract This invited perspective paper celebrating the 40th anniversary of Movement Disorders demonstrates that the topic of physical activity and exercise as a treatment for Parkinson's disease did not feature before 2002 in this journal. The topic of physical activity and exercise garnered increasing recognition over the next two decades with ...
Daniel M. Corcos, Miranda J. Munoz, Niyati Mehta, Kathleen E. McKee   +3 more
wiley   +1 more source

Neurodegeneration and glial activation related blood biomarkers in Alzheimer's disease: A systematic review and an updated meta- analysis

Experimental Gerontology
Background and objectives: This systematic review and meta-analysis aims to evaluate blood biomarkers associated with neurodegeneration and glial activation, specifically GFAP, NfL, YKL-40, MCP-1, neurogranin, GAP-43, S100B, and NSE, in individuals ...
Rasoul Ebrahimi, Amir Abbas Salehi Amniyeh Khozani, Mohammad Mahdi Masouri, Mojtaba Seifi, Anahita Hashempoor, Sana Mohammad Soltani, Shokoofe Noori   +6 more
doaj   +1 more source

Early Longitudinal Brain Network Changes in Huntington's Disease Before Clinical Motor Onset

Movement Disorders, EarlyView.
Abstract Background Longitudinal studies of seed‐based functional connectivity (SBFC) in young adult Huntington's disease gene‐expanded (HDGE) individuals are rare, and none, to our knowledge, have examined adult cohorts decades from predicted clinical motor diagnosis.
Michela Leocadi, Nicola Z. Hobbs, Mena Farag, Michael J. Murphy, Kate Fayer, Olivia Thackeray, Harry Knights, James B. Rowe, Trevor W. Robbins, Barbara J. Sahakian, Geraint Rees, Rachael I. Scahill, Sarah J. Tabrizi, Christelle Langley   +13 more
wiley   +1 more source

Consensus-Based Definitions for Vocal Biomarkers: The International VOCAL Initiative

Digital Biomarkers
Introduction: Voice-based health technologies are growing rapidly, but they lack standardized terminology, which hinders interdisciplinary collaboration, research quality, and clinical translation.
Mégane Pizzimenti, Ayush Kalia, Jamie A. Toghranegar, Mohamed Ebraheem, Nicholas Cummins, Satrajit S. Ghosh, James T. Anibal, Rhoda Au, Arian Azarang, Ruth H. Bahr, Sybille Barvaux, Steven D. Bedrick, Hugo Botha, Oita C. Coleman, Abir Elbeji, Lampros C. Kourtis, Anaïs Rameau, Jaskanwal Deep Singh Sara, Stephanie W. Watts, Daria Hemmerling, Jiri Mekyska, Marisha L. Speights, Jean-Christophe Bélisle-Pipon, Yael E. Bensoussan, Guy Fagherazzi   +24 more
doaj   +1 more source

Detection of Mild Cognitive Impairment Through Natural Language and Touchscreen Typing Processing

Frontiers in Digital Health, 2020
Mild cognitive impairment (MCI), an identified prodromal stage of Alzheimer's Disease (AD), often evades detection in the early stages of the condition, when existing diagnostic methods are employed in the clinical setting.
Anastasia Ntracha, Dimitrios Iakovakis, Stelios Hadjidimitriou, Vasileios S. Charisis, Magda Tsolaki, Leontios J. Hadjileontiadis, Leontios J. Hadjileontiadis   +6 more
doaj   +1 more source

iSense: AI-Based Model and App to Identify Linguistic Biomarkers of Mood Disorders

, 2020
The prevalence of mood disorders has increased rapidly over the past decade, especially in teens. The nature of these disorders is such that most symptoms are in a person’s mind making it harder to diagnose, leading to a mental health epidemic which is difficult to control.
openaire   +3 more sources

Artificial intelligence, equity, and pediatric neurodevelopmental disorders: A scoping review of clinical practice applications

Pediatric Investigation, EarlyView.
Artificial intelligence (AI) is being explored to support diagnosis and care for pediatric neurodevelopmental disorders, yet most tools remain in early stages of development. This scoping review identifies limited external validation, narrow population representation, and sparse equity considerations, underscoring the need for inclusive, clinically ...
Florida Uzoaru, Obinna O. Oleribe, Ucheoma Nwaozuru, Parichart Sabado   +3 more
wiley   +1 more source

Granzyme K: A new frontier in systemic lupus erythematosus

Rheumatology &Autoimmunity, EarlyView.
The role of Granzyme K in the pathogenesis of systemic lupus erythematosus and its clinical translational significance. Abstract Systemic lupus erythematosus (SLE) is a complex autoimmune disorder driven by dysregulated adaptive and innate immunity and aberrant complement activity.
Zhongyu Chen, Yunjing Pu, Peihui Yang, Qinghuan Zhu, Haojun Long, Danqi Deng   +5 more
wiley   +1 more source

The Role of Repetitive Transcranial Magnetic Stimulation in Modulating Autonomic Dysfunction in Irritable Bowel Syndrome rTMS for IBS Autonomic Dysfunction

Sensory Neuroscience, EarlyView.
Irritable bowel syndrome (IBS) is associated with dysregulation of the autonomic nervous system and altered brain–gut communication. rTMS may alleviate IBS symptoms by modulating central autonomic and pain‐processing networks, potentially restoring sympathovagal balance and reducing visceral hypersensitivity.
Aliasghar Karimi, Habib Zakeri, Mohammad Radmehr, Saba Moalemi, Pegah Pedramfard   +4 more
wiley   +1 more source