Results 51 to 60 of about 8,531 (253)

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

The CIPP-TRS Corpus: Corpus Construction and Preliminary Analyses

LingBaW
Schizophrenia, a neurodevelopmental disorder, significantly affects cognitive and linguistic functions, often resulting in disorganized speech, reduced syntactic complexity, and impaired discourse cohesion.
Laura Tagliaferro, Ludovica Fiorentino, Raffaele Guarasci, Luigi Franzese, Viviana Maria Saia, Giancarlo Spennato, Felice Iasevoli, Roberto Vitelli, Andrea de Bartolomeis, Francesca M. Dovetto   +9 more
doaj   +1 more source

When Biology Meets Medicine: A Perspective on Foundation Models

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu, Yuxing Wang, Limin Zou, Jing Huang   +3 more
wiley   +1 more source

The include network: Advancing cross-linguistic equity in brain health research. [PDF]

Alzheimers Dement
Abstract Speech and language measures are increasingly recognized as sensitive, scalable, non‐invasive markers of diverse brain disorders. Yet, current research is overwhelmingly English‐centric, neglecting the world's vast linguistic diversity and undermining these markers’ global applicability.
García AM, de Leon J, Alladi S, Battista P, Birba A, Cappa SF, Costa Beber B, Jiang J, Kemmerer D, Montembeault M, Orozco-Arroyave JR, Gorno-Tempini ML, Tee BL, Include Network.   +13 more
europepmc   +2 more sources

Alzheimer's Disease Co‐Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objectives Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) share neuropathological features, including tau, amyloid, and TDP‐43 pathology. This study investigated whether AD‐related pathological changes are associated with cognitive impairment ALS. Methods Cerebrospinal fluid (CSF total‐tau, phosphorylated‐tau, beta‐amyloid) and plasma
Elisabeth Kasper, Annaliis Lehto, Alexandra Jürs, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Voigt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Annett Halle, Jochen Herms, Anja Schneider, Stefan Teipel, Johannes Prudlo, Manuela Neumann, Andreas Hermann   +29 more
wiley   +1 more source

Neurophysiological Vocal Source Modeling for Biomarkers of Disease [PDF]

, 2016
Speech is potentially a rich source of biomarkers for detecting and monitoring neuropsychological disorders. Current biomarkers typically comprise acoustic descriptors extracted from behavioral measures of source, filter, prosodic and linguistic cues. In
Gregory Ciccarelli, Ciccarelli, Gregory A., Thomas F. Quatieri, Quatieri, Thomas F., Ghosh, Satrajit S., Satrajit S. Ghosh   +5 more
core   +1 more source

Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses

Autism Research, EarlyView.
ABSTRACT Auditory mismatch responses—mismatch negativity (MMN) and mismatch fields (MMF)—are well established electrophysiological markers of automatic auditory discrimination supported by short‐term sensory memory. These responses, typically elicited using passive oddball paradigms, are increasingly used to investigate sensory and language processing ...
Sara Cacciato‐Salcedo, Shreya Jaokar, Neil J. Ingham, Manuel S. Malmierca, Marija M. Petrinovic   +4 more
wiley   +1 more source

Master protocols in vocal biomarker development to reduce variability and advance clinical precision: a narrative review

Frontiers in Digital Health
IntroductionVocal biomarkers, defined as acoustic or linguistic features extracted from voice samples, are an emerging innovation in medical diagnostics.
Ayush Kalia, Micah Boyer, Guy Fagherazzi, Jean-Christophe Bélisle-Pipon, Yael Bensoussan   +4 more
doaj   +1 more source

Cognitive Digital Biomarkers from Automated Transcription of Spoken Language

, 2022
Background Although patients with Alzheimer’s disease and other cognitive-related neurodegenerative disorders may benefit from early detection, development of a reliable diagnostic test has remained elusive.
Kainkaryam, R., Foschini, L., Stück, D., Lemke, C., Hardy, S., Wasserman, B., Au, Rhoda, Glass, J., Nowak, C. M., Karjadi, C., Sandoval, M., Tavabi, N., Signorini, A., Hanai, T. A., Ang, T. F. A., Lavallee, M.   +15 more
core   +1 more source

Abnormal functional connectivity patterns in temporal lobe epilepsy—An international ENIGMA‐epilepsy study

Epilepsia Open, EarlyView.
Abstract Objectives Temporal lobe epilepsy (TLE) impacts multiple brain networks. Aberrant functional connectivity has been demonstrated in resting‐state networks (RSNs) that mediate higher brain functions in TLE. This study aimed to identify the reproducible patterns of altered functional connectivity in TLE in a large, international cohort through ...
Victoria Ives‐Deliperi, Jonathan Ipser, James T. Butler, Heath Pardoe, Hamid Soltanian‐Zadeh, Christian Rummel, Roland Wiest, Simon S. Keller, Barbara A. K. Kreilkamp, Anna Elisabetta Vaudano, Alice Ballerini, Stefano Meletti, Gerard Hall, Peter Taylor, Luis Concha, Alfonso Fajardo‐Valdez, Raphael Fernandes Casseb, Fernando Cendes, Clarissa L. Yasuda, Louis Lemieux, John S. Duncan, Esmaeil Davoodi‐Bodj, Orrin Devinsky, Sophia I. Thomopoulos, Dan J. Stein, Paul M. Thompson, Sanjay M. Sisodiya, Taha Gholipour, Carrie R. McDonald   +28 more
wiley   +1 more source