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Effect of using different co-ligands during 99mTc-labeling of J18 peptide on SK-MES-1 cell binding and tumor targeting [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Lung cancer is the main cause of cancer death, and its incidence is increasing worldwide. The goal of this study is to evaluate in vitro and in vivo tumor targeting behavior of [99mTc]Tc -HYNIC-(Ser)3-J18 in lung carcinoma (SK-MES-1 ...
Seyed Jalal Hosseinimehr +3 more
doaj +1 more source
Antibody–Drug Conjugates—A Tutorial Review
Molecules, 2021 Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 ADCs currently in clinical development and eleven ADCs (nine containing small ...
Stephanie Baah +2 more
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Resource for FRET-Based Biosensor Optimization
Frontiers in Cell and Developmental Biology, 2022 After the development of Cameleon, the first fluorescence resonance energy transfer (FRET)-based calcium indicator, a variety of FRET-based genetically encoded biosensors (GEBs) have visualized numerous target players to monitor their cell physiological ...
Heonsu Kim +5 more
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How Far Have We Developed Antibody–Drug Conjugate for the Treatment of Cancer?
Drugs and Drug Candidates, 2023 Cancer, also known as malignant tumour or neoplasm, is a leading cause of death worldwide. One distinct feature from normal cells is that cancerous cells often overexpress protein on the cell membrane—for instance, the overexpression of human epidermal ...
Yu Jun Lim +10 more
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Pharmaceuticals, 2023 PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology and drug discovery. This technique facilitates the complete removal of the target proteins that are “undruggable” or challenging to target through chemical molecules via
Danishuddin +5 more
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Arginine 37 of Glycine Linker Dictates Regulatory Function of HapR
Frontiers in Microbiology, 2020 HapR is designated as a high cell density quorum sensing master regulatory protein of Vibrio cholerae. It is a member of the TetR family protein and functions both as an activator and a repressor by directly communicating with cognate promoters, thus ...
Manjula Ekka +5 more
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Molecules, 2023 Prostate-specific membrane antigen (PSMA)-based low-molecular-weight agents using beta(β)-particle-emitting radiopharmaceuticals is a new treatment paradigm for patients with metastatic castration-resistant prostate cancer.
Srikanth Boinapally +10 more
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Precise Control of Molecular Self-Diffusion in Isoreticular and Multivariate Metal-Organic Frameworks. [PDF]
, 2020 Understanding the factors that affect self-diffusion in isoreticular and multivariate (MTV) MOFs is key to their application in drug delivery, separations, and heterogeneous catalysis.
Osborn Popp, Thomas M +3 more
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Microbiology Spectrum, 2022 Lytic polysaccharide monooxygenases (LPMOs) mediate oxidative degradation of plant polysaccharides. The genes encoding LPMOs are most commonly arranged with one catalytic domain, while a few are found tethered to additional noncatalytic units, i.e ...
Aishwarya Srivastava +3 more
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Progresses in research and development of antibody-drug conjugate
生物医学转化, 2021 Through referring to the literature and related databases, the research process of antibodyconjugated drugs was reviewed, and the key elements of ADC were summarized.
Wu Gang +6 more
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