Results 11 to 20 of about 4,236,805 (394)
Current ADC Linker Chemistry [PDF]
Pharmaceutical Research, 2015 The list of ADCs in the clinic continues to grow, bolstered by the success of first two marketed ADCs: ADCETRIS® and Kadcyla®. Currently, there are 40 ADCs in various phases of clinical development. However, only 34 of these have published their structures.
Jain, Nareshkumar +3 more
openaire +3 more sources
Equivariant 3D-conditional diffusion model for molecular linker design [PDF]
Nature Machine Intelligence, 2022 Fragment-based drug discovery has been an effective paradigm in early-stage drug development. An open challenge in this area is designing linkers between disconnected molecular fragments of interest to obtain chemically relevant candidate drug molecules.
Ilia Igashov +8 more
semanticscholar +1 more source
ACS Medicinal Chemistry Letters, 2022 A platform to accelerate optimization of proteolysis targeting chimeras (PROTACs) has been developed using a direct-to-biology (D2B) approach with a focus on linker effects.
Charles E. Hendrick +8 more
semanticscholar +1 more source
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Frontiers in Chemistry, 2021 Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new and exciting class of therapeutic agents that promise to significantly impact drug discovery.
Aleša Bricelj +4 more
semanticscholar +1 more source
Architecture of the linker-scaffold in the nuclear pore
Science, 2022 Description INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC).
S. Petrovic +12 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 The development of antibody-drug conjugates (ADCs) has significantly been advanced in the past decade given the improvement of payloads, linkers and conjugation methods.
Dian Su, Donglu Zhang
semanticscholar +1 more source
A Kinetic Model for the Enzymatic Action of Cellulase [PDF]
, 2009 We develop a mechanochemical model for the dynamics of cellulase, a two-domain enzyme connected by a peptide linker, as it extracts and hydrolyzes a cellulose polymer from a crystalline substrate.
Makarov, Dmitrii E. +2 more
core +2 more sources
Journal of the American Chemical Society, 2020 The stability of metal–organic frameworks (MOFs) typically decreases with an increasing number of defects, limiting the number of defects that can be created and limiting catalytic and other applications. Herein, we use a hemilabile (Hl) linker to create
Xiao Feng +14 more
semanticscholar +1 more source
Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine. [PDF]
, 2019 Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies ...
Dong, Jie-Xian +9 more
core +1 more source
Drug Delivery, 2022 Maleimides are typically applicable for coupling with reactive thiol moieties of antibodies in antibody–drug conjugates (ADCs) via the thiol-Michael click chemistry.
Yanming Wang +6 more
doaj +1 more source