Results 11 to 20 of about 4,098,264 (291)
Exploring Experimental and In Silico Approaches for Antibody–Drug Conjugates in Oncology Therapies [PDF]
Background/Objectives: Antibody–drug conjugates are a rapidly evolving class of cancer therapeutics that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. This review explores experimental and computational advances in
Vitor Martins de Almeida+2 more
doaj +2 more sources
A platform to accelerate optimization of proteolysis targeting chimeras (PROTACs) has been developed using a direct-to-biology (D2B) approach with a focus on linker effects.
Charles E. Hendrick+8 more
semanticscholar +1 more source
Architecture of the linker-scaffold in the nuclear pore
Description INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC).
S. Petrovic+12 more
semanticscholar +1 more source
Resource for FRET-Based Biosensor Optimization
After the development of Cameleon, the first fluorescence resonance energy transfer (FRET)-based calcium indicator, a variety of FRET-based genetically encoded biosensors (GEBs) have visualized numerous target players to monitor their cell physiological ...
Heonsu Kim+5 more
doaj +1 more source
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new and exciting class of therapeutic agents that promise to significantly impact drug discovery.
Aleša Bricelj+4 more
semanticscholar +1 more source
AbstractIn many languages a linker element is inserted between a noun N and a modifier or a complement of N. We focus on Albanian articles and on Iranian ezafes, and we introduce comparison data from Aromanian. In section 2, we provide arguments as to why currently available formal theories of linkers (as copulas, as case assigners, as means for ...
FRANCO, LUDOVICO+3 more
openaire +2 more sources
How Far Have We Developed Antibody–Drug Conjugate for the Treatment of Cancer?
Cancer, also known as malignant tumour or neoplasm, is a leading cause of death worldwide. One distinct feature from normal cells is that cancerous cells often overexpress protein on the cell membrane—for instance, the overexpression of human epidermal ...
Yu Jun Lim+10 more
doaj +1 more source
PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology and drug discovery. This technique facilitates the complete removal of the target proteins that are “undruggable” or challenging to target through chemical molecules via
Danishuddin+5 more
doaj +1 more source
Prostate-specific membrane antigen (PSMA)-based low-molecular-weight agents using beta(β)-particle-emitting radiopharmaceuticals is a new treatment paradigm for patients with metastatic castration-resistant prostate cancer.
Srikanth Boinapally+10 more
doaj +1 more source
Linker Histone in Diseases [PDF]
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases.
Tian Gao+5 more
openaire +3 more sources