Results 11 to 20 of about 4,098,264 (291)

Exploring Experimental and In Silico Approaches for Antibody–Drug Conjugates in Oncology Therapies [PDF]

open access: yesPharmaceuticals
Background/Objectives: Antibody–drug conjugates are a rapidly evolving class of cancer therapeutics that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. This review explores experimental and computational advances in
Vitor Martins de Almeida   +2 more
doaj   +2 more sources

Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation

open access: yesACS Medicinal Chemistry Letters, 2022
A platform to accelerate optimization of proteolysis targeting chimeras (PROTACs) has been developed using a direct-to-biology (D2B) approach with a focus on linker effects.
Charles E. Hendrick   +8 more
semanticscholar   +1 more source

Architecture of the linker-scaffold in the nuclear pore

open access: yesScience, 2022
Description INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC).
S. Petrovic   +12 more
semanticscholar   +1 more source

Resource for FRET-Based Biosensor Optimization

open access: yesFrontiers in Cell and Developmental Biology, 2022
After the development of Cameleon, the first fluorescence resonance energy transfer (FRET)-based calcium indicator, a variety of FRET-based genetically encoded biosensors (GEBs) have visualized numerous target players to monitor their cell physiological ...
Heonsu Kim   +5 more
doaj   +1 more source

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

open access: yesFrontiers in Chemistry, 2021
Proteolysis-targeting chimeras (PROTACs) have received tremendous attention as a new and exciting class of therapeutic agents that promise to significantly impact drug discovery.
Aleša Bricelj   +4 more
semanticscholar   +1 more source

Linkers and agreement [PDF]

open access: yesThe Linguistic Review, 2015
AbstractIn many languages a linker element is inserted between a noun N and a modifier or a complement of N. We focus on Albanian articles and on Iranian ezafes, and we introduce comparison data from Aromanian. In section 2, we provide arguments as to why currently available formal theories of linkers (as copulas, as case assigners, as means for ...
FRANCO, LUDOVICO   +3 more
openaire   +2 more sources

How Far Have We Developed Antibody–Drug Conjugate for the Treatment of Cancer?

open access: yesDrugs and Drug Candidates, 2023
Cancer, also known as malignant tumour or neoplasm, is a leading cause of death worldwide. One distinct feature from normal cells is that cancerous cells often overexpress protein on the cell membrane—for instance, the overexpression of human epidermal ...
Yu Jun Lim   +10 more
doaj   +1 more source

Revolutionizing Drug Targeting Strategies: Integrating Artificial Intelligence and Structure-Based Methods in PROTAC Development

open access: yesPharmaceuticals, 2023
PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology and drug discovery. This technique facilitates the complete removal of the target proteins that are “undruggable” or challenging to target through chemical molecules via
Danishuddin   +5 more
doaj   +1 more source

Preclinical Evaluation of a New Series of Albumin-Binding 177Lu-Labeled PSMA-Based Low-Molecular-Weight Radiotherapeutics

open access: yesMolecules, 2023
Prostate-specific membrane antigen (PSMA)-based low-molecular-weight agents using beta(β)-particle-emitting radiopharmaceuticals is a new treatment paradigm for patients with metastatic castration-resistant prostate cancer.
Srikanth Boinapally   +10 more
doaj   +1 more source

Linker Histone in Diseases [PDF]

open access: yesInternational Journal of Biological Sciences, 2017
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases.
Tian Gao   +5 more
openaire   +3 more sources

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